ArticleHuman reproduction (Oxford, England)2010
What next for preimplantation genetic screening? A polar body approach!
Article in Human reproduction (Oxford, England), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed.
- Polar body based aneuploidy screening is poorly predictive of embryo ploidy and reproductive potential.Journal of assisted reproduction and genetics · 2014Trial
- Preimplantation Genetic Testing: Where We Are Today.International journal of molecular sciences · 2020Review
- Preimplantation genetic screening 2.0: the theory.Molecular human reproduction · 2016Review
- OMICS: Current and future perspectives in reproductive medicine and technology.Journal of human reproductive sciences · 2014Review
- Current issues in medically assisted reproduction and genetics in Europe: research, clinical practice, ethics, legal issues and policy. European Society of Human Genetics and European Society of Human Reproduction and Embryology.European journal of human genetics : EJHG · 2013Article
- Embryos whose polar bodies contain isolated reciprocal chromosome aneuploidy are almost always euploid.Human reproduction (Oxford, England) · 2013Article
- A review of, and commentary on, the ongoing second clinical introduction of preimplantation genetic screening (PGS) to routine IVF practice.Journal of assisted reproduction and genetics · 2012Review
- Multiple meiotic errors caused by predivision of chromatids in women of advanced maternal age undergoing in vitro fertilisation.European journal of human genetics : EJHG · 2012Article
- Delivery of a chromosomally normal child from an oocyte with reciprocal aneuploid polar bodies.Journal of assisted reproduction and genetics · 2012Article
- Preimplantation genetic diagnosis: state of the art 2011.Human genetics · 2012Review
- New array approaches to explore single cells genomes.Frontiers in genetics · 2012Article
- Use of parthenogenetic activation of human oocytes as an experimental model for evaluation of polar body based PGD assay performance.Journal of assisted reproduction and genetics · 2011Article
- Frequency of aneuploidy related to age in porcine oocytes.PloS one · 2011Article
- Predicting aneuploidy in human oocytes: key factors which affect the meiotic process.Human reproduction (Oxford, England) · 2010Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Screening of human preimplantation embryos for numerical chromosome abnormalities has been conducted mostly at the preimplantation stage using fluorescence in situ hybridization. However, it is clear that preimplantation genetic screening (PGS) as it is currently practiced does not improve live birth rates. Therefore the ESHRE PGS Task Force has decided to start a proof of principle study with the aim of determining whether biopsy of the first and second polar body followed by subsequent analysis of the complete chromosome complement of these polar bodies using an array based technique enables a timely identification of the chromosomal status of an oocyte. If the principle of this approach can be proven, it is obvious that a multicentre randomized controlled trial should then be started to determine the clinical value of this technique. In this way the ESHRE PGS Task Force hopes to redirect preimplantation screening from the blind alley to the main road of assisted reproduction.
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