ArticleCirculation. Cardiovascular genetics2009
Disruption of the aortic elastic lamina and medial calcification share genetic determinants in mice.
Article in Circulation. Cardiovascular genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 15 citations in OpenAlex.
- ABCC6 Involvement in Cerebral Small Vessel Disease: Potential Mechanisms and Associations.Genes · 2025Review
- Regulatory Role of Sex Hormones in Cardiovascular Calcification.International journal of molecular sciences · 2021Review
- ABCC6 deficiency promotes dyslipidemia and atherosclerosis.Scientific reports · 2021Article
- Transcription Factor Zhx2 Deficiency Reduces Atherosclerosis and Promotes Macrophage Apoptosis in Mice.Arteriosclerosis, thrombosis, and vascular biology · 2018Article
- The ABCC6 Transporter as a Paradigm for Networking from an Orphan Disease to Complex Disorders.BioMed research international · 2015Review
- RANKL-OPG and RAGE modulation in vascular calcification and diabetes: novel targets for therapy.Diabetologia · 2014Review
- Systems Biology Approaches and Applications in Obesity, Diabetes, and Cardiovascular Diseases.Current cardiovascular risk reports · 2013Article
- The vascular phenotype in Pseudoxanthoma elasticum and related disorders: contribution of a genetic disease to the understanding of vascular calcification.Frontiers in genetics · 2013Article
- Genetic pathways of vascular calcification.Trends in cardiovascular medicine · 2012Review
- Genetics in arterial calcification: pieces of a puzzle and cogs in a wheel.Circulation research · 2011Review
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 3 countries.
Funding
Abstract
backgroundDisruption of the elastic lamina, as an early indicator of aneurysm formation, and vascular calcification frequently occur together in atherosclerotic lesions of humans. METHODS AND
resultsWe now report evidence of shared genetic basis for disruption of the elastic lamina (medial disruption) and medial calcification in an F(2) mouse intercross between C57BL/6J and C3H/HeJ on a hyperlipidemic apolipoprotein E (ApoE(-/-)) null
backgroundgene, known to mediate myocardial calcification. Using transgenic complementation, we show that Abcc6 also contributes to aortic medial calcification.
conclusionsOur data indicate that calcification, though possibly contributory, does not always lead to medial disruption and that in addition to aneurysm formation, medial disruption may be the precursor to calcification.
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