ArticleBMC developmental biology2009
ERG is required for the differentiation of embryonic stem cells along the endothelial lineage.
Article in BMC developmental biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed.
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- Universal method for the isolation of microvessels from frozen brain tissue: A proof-of-concept multiomic investigation of the neurovasculature.Brain, behavior, & immunity - health · 2023Article
- Genetically engineering endothelial niche in human kidney organoids enables multilineage maturation, vascularization and de novo cell types.bioRxiv : the preprint server for biology · 2023Article
- Blood endothelial ALK1-BMP4 signaling axis regulates adult hair follicle stem cell activation.The EMBO journal · 2023Article
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- Cooperative ETS Transcription Factors Enforce Adult Endothelial Cell Fate and Cardiovascular Homeostasis.Nature cardiovascular research · 2022Article
- Ketone body oxidation increases cardiac endothelial cell proliferation.EMBO molecular medicine · 2022Article
- Review
- The potential role of exosomal miRNAs and membrane proteins in acute HIV-infected people.Frontiers in immunology · 2022Article
- Vascular architectural patterns in clear cell renal cell carcinoma and clear cell papillary renal cell carcinoma.Virchows Archiv : an international journal of pathology · 2021Article
- Endothelial ERG alleviates cardiac fibrosis via blocking endothelin-1-dependent paracrine mechanism.Cell biology and toxicology · 2021Article
- Slit2-Robo Signaling Promotes Glomerular Vascularization and Nephron Development.Journal of the American Society of Nephrology : JASN · 2021Article
- Dihydroartemisinin inhibits the expression of von Willebrand factor by downregulation of transcription factor ERG in endothelial cells.Fundamental & clinical pharmacology · 2021Article
- Development and Application of Endothelial Cells Derived From Pluripotent Stem Cells in Microphysiological Systems Models.Frontiers in cardiovascular medicine · 2021Review
- Identification of a Goat Intersexuality-Associated Novel Variant Through Genome-Wide Resequencing and Hi-C.Frontiers in genetics · 2020Article
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9 authors.
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Abstract
backgroundThe molecular mechanisms that govern stem cell differentiation along the endothelial lineage remain largely unknown. Ets related gene (ERG) has recently been shown to participate in the transcriptional regulation of a number of endothelial specific genes including VE-cadherin (CD144), endoglin, and von Willebrand's Factor (vWF). The specific role of the ETS factor ERG during endothelial differentiation has not been evaluated.
resultsERG expression and function were evaluated during the differentiation of embryonic stem cells into embryoid bodies (EB). The results of our study demonstrate that ERG is first expressed in a subpopulation of vascular endothelial growth factor receptor 2 (VEGF-R2) expressing cells that also express VE-cadherin. During ES cell differentiation, ERG expression remains restricted to cells of the endothelial lineage that eventually coalesce into primitive vascular structures within embryoid bodies. ERG also exhibits an endothelial cell (EC)-restricted pattern during embryogenesis. To further define the role of ERG during ES cell differentiation, we used a knockdown strategy to inhibit ERG expression. Delivery of three independent shRNA led to 70-85% reductions in ERG expression during ES cell differentiation compared to no change with control shRNA. ERG knockdown was associated with a marked reduction in the number of ECs, the expression of EC-restricted genes, and the formation of vascular structures.
conclusionThe ETS factor ERG appears to be a critical regulator of EC differentiation.
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