ReviewScandinavian journal of trauma, resuscitation and emergency medicine2009
Hypothermia in bleeding trauma: a friend or a foe?
Review in Scandinavian journal of trauma, resuscitation and emergency medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 76 citations in OpenAlex.
- Hemodynamic Stability to Surface Warming and Cooling During Sustained and Continuous Simulated Hemorrhage in Humans.Shock (Augusta, Ga.) · 2016Trial
- Topical menthol, ice, peripheral blood flow, and perceived discomfort.Journal of athletic trainingTrial
- Recombinant Klotho Protein Protects Tissues by Mitigating the Detrimental Effects of Sterile Inflammation After Hemorrhagic Shock.Shock (Augusta, Ga.) · 2026Article
- Factors associated with hypothermia and its response to resuscitation among major trauma patients at St Francis Hospital Nsambya: a prospective observational study.BMC emergency medicine · 2025Observational
- Navigating Hemorrhagic Shock: Biomarkers, Therapies, and Challenges in Clinical Care.Biomedicines · 2024Review
- Cold temperature induces a TRPM8-independent calcium release from the endoplasmic reticulum in human platelets.PloS one · 2024Article
- Prevalence of Postoperative Hypothermia in the Post-anesthesia Care Unit.Anesthesiology and pain medicine · 2023Article
- Cold temperature induces a TRPM8-independent calcium release from the endoplasmic reticulum in human platelets.bioRxiv : the preprint server for biology · 2023Article
- Platelet Hemostasis Reactions at Different Temperatures Correlate with Intracellular Calcium Concentration.International journal of molecular sciences · 2022Article
- Transrectal intracolon cooling prevents paraplegia and mortality in a rat model of aortic occlusion-induced spinal cord ischemia.JVS-vascular science · 2021Article
- Article
- Valproic acid protects against haemorrhagic shock-induced signalling changes via PPARγ activation in an in vitro model.British journal of pharmacology · 2015Article
- Hypothermia: effects on platelet function and hemostasis.Thrombosis journal · 2014Article
- Potential role of therapeutic hypothermia in the salvage of traumatic hemorrhagic shock.Critical care (London, England) · 2013Review
- Critical care considerations in the management of the trauma patient following initial resuscitation.Scandinavian journal of trauma, resuscitation and emergency medicine · 2012Review
- New trends in resuscitation.Current problems in surgery · 2011Article
- Advances in resuscitation strategies.International journal of surgery (London, England) · 2011Review
- Year in review 2010: Critical Care--Cardiac arrest and cardiopulmonary resuscitation.Critical care (London, England) · 2011Review
- Should patients with haemorrhage be kept warm?The Journal of physiology · 2010Review
- A review of metabolic staging in severely injured patients.Scandinavian journal of trauma, resuscitation and emergency medicine · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The induction of hypothermia for cellular protection is well established in several clinical settings. Its role in trauma patients, however, is controversial. This review discusses the benefits and complications of induced hypothermia--emphasizing the current state of knowledge and potential applications in bleeding patients. Extensive pre-clinical data suggest that in advanced stages of shock, rapid cooling can protect cells during ischemia and reperfusion, decrease organ damage, and improve survival. Yet hypothermia is a double edged sword; unless carefully managed, its induction can be associated with a number of complications. Appropriate patient selection requires a thorough understanding of the pre-clinical literature. Clinicians must also appreciate the enormous influence that temperature modulation exerts on various cellular mechanisms. This manuscript aims to provide a balanced view of the published literature on this topic. While many of the advantageous molecular and physiological effects of induced hypothermia have been outlined in animal models, rigorous clinical investigations are needed to translate these promising findings into clinical practice.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.