ReviewCNS drugs2010
Role of antiepileptic drugs as preventive agents for migraine.
Review in CNS drugs, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 45 citations in OpenAlex.
- Pharmacological interventions for prophylaxis of vestibular migraine.The Cochrane database of systematic reviews · 2023Pooled it
- Understanding the nature of psychiatric comorbidity in migraine: a systematic review focused on interactions and treatment implications.The journal of headache and pain · 2019Pooled it
- Intracortical facilitation within the migraine motor cortex depends on the stimulation intensity. A paired-pulse TMS study.The journal of headache and pain · 2018Trial
- Efficacy and tolerability of pregabalin as preventive treatment for migraine: a 3-month follow-up study.The journal of headache and pain · 2011Trial
- Advancements in Valproate Therapy for Seizures, Migraines, and Bipolar Disorders.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2025Review
- Gender Minority Stress, Psychiatric Comorbidities, and the Experience of Migraine in Transgender and Gender-Diverse Individuals: a Narrative Review.Current pain and headache reports · 2021Review
- Pathophysiological Bases of Comorbidity in Migraine.Frontiers in human neuroscience · 2021Review
- [Chronic migraine].Der Nervenarzt · 2013Review
- Migraine, stroke and epilepsy: underlying and interrelated causes, diagnosis and treatment.Current treatment options in cardiovascular medicine · 2013Article
- Sodium valproate exposure during the brain growth spurt transiently impairs spatial learning in prepubertal rats.Pharmacology, biochemistry, and behavior · 2013Article
- Future trends in drugs for migraine prophylaxis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2012Review
- Italian guidelines for primary headaches: 2012 revised version.The journal of headache and pain · 2012Article
- Topiramate related reversible erectile dysfunction in temporal lobe epilepsy.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2012Article
- Preventive agents for migraine: focus on the antiepileptic drugs.Journal of central nervous system disease · 2012Article
- Migraine prophylaxis: what is new and what we need?Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2011Review
- The effects of body mass index on the treatment of the patients with migraine headaches.Iranian journal of neurology · 2011Article
- Efficacy of combined topiramate/thioctic acid therapy in migraine prophylaxis.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2010Article
- Difficulties in Treatment and Management of Epilepsy and Challenges in New Drug Development.Pharmaceuticals (Basel, Switzerland) · 2010Review
- Therapeutic strategies in migraine patients with mood and anxiety disorders: clinical evidence.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Migraine is a common neurological disease affecting about 12% of the population in Western Europe and North America, and causing a considerable burden both to migraineurs and to society. Severe, frequent and disabling migraine attacks, as well as those poorly responsive to acute care medication, require preventive treatment, which is often under-utilized. Antiepileptic drugs are used in the prevention of migraine. We performed a literature search of PubMed through June 2008 for controlled trials of antiepileptic drugs in the prevention of migraine. The search identified 70 papers for a full-text review. The majority of these papers referred to valproate and topiramate, and showed that these drugs are effective and well tolerated in migraine prevention and are suitable for first-line clinical use. On the other hand, acetazolamide, lamotrigine, oxcarbazepine and vigabatrin have been shown to be not effective and gabapentin requires further evaluation. For the rest of the antiepileptic drugs, no data from controlled trials are available.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.