ArticleCancer2010
Quantitative assessment of cardiorespiratory fitness, skeletal muscle function, and body composition in adults with primary malignant glioma.
Article in Cancer, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 50 citations in OpenAlex.
- Physical activity and exercise in adults diagnosed with primary brain cancer: a systematic review.Journal of neuro-oncology · 2021Pooled it
- Controlled rehabilitative and supportive care intervention trials in patients with high-grade gliomas and their caregivers: a systematic review.BMJ supportive & palliative care · 2016Pooled it
- Trial
- Strength of skeletal muscle and self-reported physical performance in Austrian glioblastoma-patients.Wiener klinische Wochenschrift · 2012Trial
- Promoting physical activity in glioma patients: Insights from Dutch healthcare professionals.Neuro-oncology practice · 2026Article
- Self-reported physical functioning and physical fitness in glioma patients.Neuro-oncology practice · 2026Article
- Enhancing cardiorespiratory fitness and quality of life in high-grade glioma through an intensive exercise intervention during chemotherapy: Proof of concept.Neuro-oncology · 2025Article
- Measures of physical functioning in adults with brain tumor associated with functional outcomes: A scoping review.Neuro-oncology practice · 2025Review
- Maximal cardiopulmonary exercise testing in glioblastoma patients undergoing chemotherapy: assessment of feasibility, safety, and physical fitness status.Journal of neuro-oncology · 2024Article
- A feasibility, safety, and efficacy evaluation of supervised aerobic and resistance exercise for patients with glioblastoma undertaking adjuvant chemoradiotherapy.Neuro-oncology practice · 2023Article
- Easing the Journey-an Updated Review of Palliative Care for the Patient with High-Grade Glioma.Current oncology reports · 2022Review
- Imaging modalities for diagnosis and monitoring of cancer cachexia.EJNMMI research · 2021Review
- Physical functional capacity of patients with glioma prior to adjuvant radiation: preliminary descriptive study.Neuro-oncology practice · 2021Article
- Feasibility, Safety and Effects of a One-Week, Ski-Based Exercise Intervention in Brain Tumor Patients and Their Relatives: A Pilot Study.Journal of clinical medicine · 2020Article
- Compliance and safety of a novel home exercise program for patients with high-grade brain tumors, a prospective observational study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2017Observational
- Muscle mass as a target to reduce fatigue in patients with advanced cancer.Journal of cachexia, sarcopenia and muscle · 2017Observational
- Exercise preferences and associations between fitness parameters, physical activity, and quality of life in high-grade glioma patients.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2017Article
- Article
- Cardiorespiratory fitness in long-term lymphoma survivors after high-dose chemotherapy with autologous stem cell transplantation.British journal of cancer · 2016Article
- Making the most of the imaging we have: using head MRI to estimate body composition.Clinical radiology · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThe study was undertaken to evaluate cardiorespiratory fitness, skeletal muscle function, and body composition of patients with newly diagnosed and untreated, postsurgical primary malignant glioma.
methodsBy using a cross-sectional design, patients with clinically stable (10 +/- 7 days postsurgery) high-grade glioma (HGG; n = 25) or low-grade glioma (LGG; n = 10) were studied. Participants performed a cardiopulmonary exercise test (CPET) with expired gas analysis to assess cardiorespiratory fitness (peak oxygen consumption, VO2peak). Other physiological outcomes included skeletal muscle cross-sectional area (CSA; magnetic resonance imaging), isokinetic muscle strength (isokinetic dynamometer), and body composition (air displacement plethysmography). Quality of life was assessed with the Functional Assessment of Cancer Therapy-Brain scale.
resultsCPET was a feasible and safe procedure to assess VO2peak, with no serious adverse events. VO2peak indexed to total body weight and lean body mass (LBM) for both groups was 13.0 mL x weight x min(-1) and 19 mL x LBM x min(-1), the equivalent to 59% and 38% below age- and sex-predicted normative values, respectively. Skeletal muscle strength and mid-thigh CSA were lower in HGG relative to LGG patients (83 vs 125 Nm, P = .025; 94 vs 119 cm2, P = .171, respectively). Skeletal muscle isokinetic strength, CSA, and body composition outcomes predicted VO2peak (r = -0.59 to 0.68, P < .05).
conclusionsPostsurgical glioma patients have markedly reduced cardiorespiratory fitness, isokinetic strength, and CSA. Prospective studies are now required to determine whether such abnormalities influence treatment toxicity and clinical outcome as well as to test the effect of appropriately selected interventions to prevent and/or mitigate dysfunction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.