ArticleAmerican journal of hematology2010
Genetic polymorphisms in the metabolic pathway and non-Hodgkin lymphoma survival.
Article in American journal of hematology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 26 citations in OpenAlex.
- Trial
- An Updated Overview of the Role of CYP450 during Xenobiotic Metabolization in Regulating the Acute Myeloid Leukemia Microenvironment.International journal of molecular sciences · 2023Review
- Clinicopathological Characteristics and Molecular Phenotypes of Primary Hepatic Lymphoma.Frontiers in oncology · 2022Article
- Article
- Thyroid hormones induce doxorubicin chemosensitivity through enzymes involved in chemotherapy metabolism in lymphoma T cells.Oncotarget · 2019Article
- Comprehensive strategy for the design of precision drugs and identification of genetic signature behind proneness of the disease-a pharmacogenomic approach.Functional & integrative genomics · 2017Article
- Methodology for single nucleotide polymorphism selection in promoter regions for clinical use. An example of its applicability.International journal of molecular epidemiology and genetics · 2016Article
- Effects of polymorphisms in alcohol metabolism and oxidative stress genes on survival from head and neck cancer.Cancer epidemiology · 2013Article
- Polymorphisms in NAT2 and GSTP1 are associated with survival in oral and oropharyngeal cancer.Cancer epidemiology · 2013Article
- Integrative analysis of cancer prognosis data with multiple subtypes using regularized gradient descent.Genetic epidemiology · 2012Article
- Over-expression of CYP2E1 mRNA and protein: implications of xenobiotic induced damage in patients with de novo acute myeloid leukemia with inv(16)(p13.1q22); CBFβ-MYH11.International journal of environmental research and public health · 2012Article
- Risk Factors of Non-Hodgkin Lymphoma.Expert opinion on medical diagnostics · 2011Article
- Host genetics in follicular lymphoma.Best practice & research. Clinical haematology · 2011Review
- SNP rs6457327 in the HLA region on chromosome 6p is predictive of the transformation of follicular lymphoma.Blood · 2011Article
- Identification of predictive pathways for non-hodgkin lymphoma prognosis.Cancer informatics · 2010Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Metabolic pathway enzymes, such as Cytochrome P450 (CYP), glutathione S-transferase (GST), and N-acetyltransferases (NAT) are involved in activation and detoxification of environmental carcinogens as well as drug metabolism. We hypothesized that the genetic variations in such metabolic pathways may affect NHL prognosis and survival. Follow-up information of 496 female NHL incident cases diagnosed during 1996-2000 in Connecticut were abstracted from the Connecticut Tumor Registry in 2008; survival analyses were conducted by comparing the Kaplan-Meier curves, and hazard ratios (HR) were computed from the Cox Proportional Hazard models adjusting for demographic and tumor characteristics which were suggested by previous studies to be determinants of NHL survival. We identified six SNPs from four metabolism genes (CYP2E1, GSTP1, GSTT1, and NAT1) that were associated with NHL survival. Specifically, polymorphisms in GSTT1 were associated with follicular lymphoma survival; and polymorphisms in CYP2E1, GSTP1, and NAT1 were associated with survival of chronic lymphocytic leukemia/small lymphocytic lymphoma. Our study suggests that genetic polymorphisms in metabolic pathways may help improve the prediction of NHL survival and prognosis.
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Registered trials
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