ArticleAmerican journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics2010
Polymorphisms in CRHR1 and the serotonin transporter loci: gene x gene x environment interactions on depressive symptoms.
Article in American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 3 of them syntheses that pooled it.
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Who cites it
64 citing papers in PubMed, 3 syntheses or guidelines pooled it, 140 citations in OpenAlex.
- Systems Approach to Identify Common Genes and Pathways Associated with Response to Selective Serotonin Reuptake Inhibitors and Major Depression Risk.International journal of molecular sciences · 2019Pooled it
- Do racial patterns in psychological distress shed light on the Black-White depression paradox? A systematic review.Social psychiatry and psychiatric epidemiology · 2017Pooled it
- The serotonin transporter promoter variant (5-HTTLPR), stress, and depression meta-analysis revisited: evidence of genetic moderation.Archives of general psychiatry · 2011Pooled it
- Hippocampal SGK1 promotes vulnerability to depression: the role of early life adversity, stress, and genetic risk.Molecular psychiatry · 2025Article
- Molecular Mechanisms of Depression: The Interplay Between Genes and Receptors.International journal of molecular sciences · 2025Review
- Association of clinical phenotypes of depression with comorbid conditions, treatment patterns and outcomes: a 10-year region-based cohort study.Translational psychiatry · 2024Observational
- Stress and the CRH System, Norepinephrine, Depression, and Type 2 Diabetes.Biomedicines · 2024Review
- Genotypic variation in the promoter region of the CRH-248 gene interacts with early rearing experiences to disrupt the development of the HPA axis in infant rhesus macaques (Stress (Amsterdam, Netherlands) · 2024Article
- Gene-by-Environment Interaction in Non-Alcoholic Fatty Liver Disease and Depression: The Role of Hepatic Transaminases.Medical research archives · 2023Article
- By what molecular mechanisms do social determinants impact cardiometabolic risk?Clinical science (London, England : 1979) · 2023Review
- Non-alcoholic Fatty Liver Disease and Depression: Evidence for Genotype × Environment Interaction in Mexican Americans.Frontiers in psychiatry · 2022Article
- Multiomic biological approaches to the study of child abuse and neglect.Pharmacology, biochemistry, and behavior · 2021Review
- Article
- TheFrontiers in psychiatry · 2021Article
- Plasticity of the Reward Circuitry After Early-Life Adversity: Mechanisms and Significance.Biological psychiatry · 2020Review
- Altered Global mRNA Expressions of Pain and Aggression Related Genes in the Blood of Children with Autism Spectrum Disorders.Journal of molecular neuroscience : MN · 2019Article
- Childhood Trauma in Schizophrenia: Current Findings and Research Perspectives.Frontiers in neuroscience · 2019Review
- Corticotropin-releasing factor 1 receptor haplotype and cognitive features of major depression.Translational psychiatry · 2018Review
- Early Life Stress, Mood, and Anxiety Disorders.Chronic stress (Thousand Oaks, Calif.) · 2017Article
- The CRF System as a Therapeutic Target for Neuropsychiatric Disorders.Trends in pharmacological sciences · 2016Review
4 more citing papers are in PubMed but not listed here.
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
Gene x environment (G x E) interactions mediating depressive symptoms have been separately identified in the stress-sensitive serotonergic (5-HTTLPR) and corticotropin-releasing hormone (CRHR1) systems. Our objective was to examine whether the effects of child abuse are moderated by gene x gene (G x G) interactions between CRHR1 and 5-HTTLPR polymorphisms. We used an association study examining G x G x E interactions of CRHR1 and 5-HTTLPR polymorphisms and measures of child abuse on adult depressive symptomatology. The participant population (N = 1,392) was African-American, of low socioeconomic status (60% with <$1,000/month family income), and with high rates of childhood and lifetime trauma. Depressive symptoms were measured with Beck Depression Inventory (BDI) and history of Major Depression by Structure Clinical Interview based on DSM-IV (SCID). We first replicated an interaction of child abuse and 5-HTTLPR on lifetime SCID diagnosis of major depression in a subsample (N = 236) of the study population-the largest African-American 5-HTTLPR cohort reported to date. We then extended our previously reported interaction with both a CRHR1 SNP (rs110402) and TCA haplotype interacting with child abuse to predict current symptoms (N = 1,059; P = 0.0089). We found that the 5-HTTLPR S allele interacted with CRHR1 haplotypes and child abuse to predict current depressive symptoms (N = 856, P = 0.016). These data suggest that G x E interactions predictive of depressive symptoms may be differentially sensitive to levels of childhood trauma, and the effects of child abuse are moderated by genetic variation at both the CRHR1 and 5-HTTLPR loci and by their G x G interaction.
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