ReviewAutism research : official journal of the International Society for Autism Research2009
Autism spectrum and obsessive-compulsive disorders: OC behaviors, phenotypes and genetics.
Review in Autism research : official journal of the International Society for Autism Research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 3 syntheses or guidelines pooled it, 86 citations in OpenAlex.
- Pharmacotherapy of restricted/repetitive behavior in autism spectrum disorder:a systematic review and meta-analysis.BMC psychiatry · 2020Pooled it
- Systematic Review: Overlap Between Eating, Autism Spectrum, and Attention-Deficit/Hyperactivity Disorder.Frontiers in psychiatry · 2019Pooled it
- Pharmacologic treatment of repetitive behaviors in autism spectrum disorders: evidence of publication bias.Pediatrics · 2012Pooled it
- Obsessive-Compulsive Disorder (OCD) and Autism Spectrum Disorder (ASD): Clinical Fingerprints of the Comorbidity.Life (Basel, Switzerland) · 2026Article
- Article
- Underdiagnosed and Misunderstood: Clinical Challenges and Educational Needs of Healthcare Professionals in Identifying Autism Spectrum Disorder in Women.Behavioral sciences (Basel, Switzerland) · 2025Review
- The midline thalamic nucleus reuniens promotes compulsive-like grooming in rodents.Translational psychiatry · 2025Article
- Phenomenology of repetitive and restrictive behaviors and sensory phenomena in neurodevelopmental disorders: an exploratory study.BMC psychiatry · 2025Article
- CNVDeep: deep association of copy number variants with neurocognitive disorders.BMC bioinformatics · 2024Article
- Prevalence and Correlates of the Concurrence of Autism Spectrum Disorder and Obsessive Compulsive Disorder in Children and Adolescents: A Systematic Review and Meta-Analysis.Brain sciences · 2024Review
- Autistic Traits as Predictors of Increased Obsessive-Compulsive Disorder Severity: The Role of Inflexibility and Communication Impairment.Brain sciences · 2024Article
- Effects of Augmented Reality Game-Based Cognitive-Motor Training on Restricted and Repetitive Behaviors and Executive Function in Patients with Autism Spectrum Disorder.Healthcare (Basel, Switzerland) · 2022Article
- The Clinical Implications of the Academic Performance of the Siblings of Individuals With Autism Spectrum Disorder.Cureus · 2022Review
- Memantine treatment does not affect compulsive behavior or frontostriatal connectivity in an adolescent rat model for quinpirole-induced compulsive checking behavior.Psychopharmacology · 2022Article
- Review
- Innate Preferences Affect Results of Object Recognition Task in Wild Type and Alzheimer's Disease Mouse Models.Journal of Alzheimer's disease : JAD · 2022Article
- Reduced DNA methylation of the oxytocin receptor gene is associated with obsessive-compulsive disorder.Clinical epigenetics · 2020Article
- Family Accommodation in Autism Spectrum Disorder.Journal of autism and developmental disorders · 2019Article
- The Effect of ASIC3 Knockout on Corticostriatal Circuit and Mouse Self-grooming Behavior.Frontiers in cellular neuroscience · 2019Article
- Activation of Serotonin 5-HTFrontiers in molecular neuroscience · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Autism spectrum disorders (ASDs) are a phenotypically and etiologically heterogeneous set of disorders that include obsessive-compulsive behaviors (OCB) that partially overlap with symptoms associated with obsessive-compulsive disorder (OCD). The OCB seen in ASD vary depending on the individual's mental and chronological age as well as the etiology of their ASD. Although progress has been made in the measurement of the OCB associated with ASD, more work is needed including the potential identification of heritable endophenotypes. Likewise, important progress toward the understanding of genetic influences in ASD has been made by greater refinement of relevant phenotypes using a broad range of study designs, including twin and family-genetic studies, parametric and nonparametric linkage analyses, as well as candidate gene studies and the study of rare genetic variants. These genetic analyses could lead to the refinement of the OCB phenotypes as larger samples are studied and specific associations are replicated. Like ASD, OCB are likely to prove to be multidimensional and polygenic. Some of the vulnerability genes may prove to be generalist genes influencing the phenotypic expression of both ASD and OCD while others will be specific to subcomponents of the ASD phenotype. In order to discover molecular and genetic mechanisms, collaborative approaches need to generate shared samples, resources, novel genomic technologies, as well as more refined phenotypes and innovative statistical approaches. There is a growing need to identify the range of molecular pathways involved in OCB related to ASD in order to develop novel treatment interventions.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.