ArticleMolecular vision2009
Association of tumor necrosis factor alpha gene polymorphism G-308A with pseudoexfoliative glaucoma in the Pakistani population.
Article in Molecular vision, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Roles of tumor necrosis factor alpha gene polymorphisms, tumor necrosis factor alpha level in aqueous humor, and the risks of open angle glaucoma: a meta-analysis.Molecular vision · 2013Pooled it
- Is pseudoexfoliation glaucoma a neurodegenerative disorder?Journal of biosciences · 2021Review
- Elevated levels of plasma tumor necrosis factor alpha in patients with pseudoexfoliation glaucoma.Clinical ophthalmology (Auckland, N.Z.) · 2018Article
- Risk of open angle glaucoma due to tumor necrosis factor alpha gene polymorphisms.Electronic physician · 2016Article
- Evaluation of genetic polymorphisms in clusterin and tumor necrosis factor-alpha genes in South Indian individuals with pseudoexfoliation syndrome.Current eye research · 2015Article
- Genetics of exfoliation syndrome and glaucoma.International ophthalmology clinics · 2014Review
- Analysis of COCH and TNFA variants in East Indian primary open-angle glaucoma patients.BioMed research international · 2013Article
- Pseudoexfoliation syndrome, a systemic disorder with ocular manifestations.Human genomics · 2012Review
- Glaucomatous neurodegeneration: an eye on tumor necrosis factor-alpha.Indian journal of ophthalmology · 2012Review
- Role of Lysyl oxidase-like 1 gene polymorphisms in Pakistani patients with pseudoexfoliative glaucoma.Molecular vision · 2012Article
- Polymorphism in the TNF-α(-863) locus associated with reduced risk of primary open angle glaucoma.Molecular vision · 2012Article
- Genetics and genomics of pseudoexfoliation syndrome/glaucoma.Middle East African journal of ophthalmology · 2011Article
- The association of glutathione S-transferase GSTT1 and GSTM1 gene polymorphism with pseudoexfoliative glaucoma in a Pakistani population.Molecular vision · 2010Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe purpose of the present study was to determine the role of the tumor necrosis factor alpha (TNF-alpha) gene polymorphism G-308A and total serum immunoglobulin E (TsIgE) levels in the onset of pseudoexfoliation glaucoma (PEXG) in Pakistani patients.
methodsThe TNF-alpha polymorphism G-308A was analyzed in 122 patients with PEXG and 126 healthy unrelated controls by using polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP). TsIgE levels were determined by solid-phase enzyme-linked immunosorbent assay (ELISA).
resultsThe AA and GA genotypes were strongly associated with PEXG (p<0.001), with an odds ratio (OR) of 0.07 (95% confidence interval [CI]=0.02-0.27) and 0.24 (95% CI=0.12-0.51), respectively, while the GG genotype was found at a higher frequency in controls as compared to patients (p<0.001) OR=8.95 (95% CI=4.55-17.81). No significant difference was found in TsIgE levels of both patients and controls (p=0.86).
conclusionThe present study concludes that the TNF-alpha polymorphism G-308A is strongly associated with PEXG. To our knowledge this is the first study in southeast Asia which demonstrates a strong association of a TNF-alpha polymorphism with PEXG.
Indexed as
Identifiers
20029655PMC2796874W2118276771What OpenQuestion holds
Registered trials
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