Evidence map›Paper›PMID 20029632›Full record

ReviewJournal of biomedicine & biotechnology2010

Challenges for biomarker discovery in body fluids using SELDI-TOF-MS.

Muriel De Bock, Dominique de Seny, Marie-Alice Meuwis, Jean-Paul Chapelle, Edouard Louis, Michel Malaise, Marie-Paule Merville, Marianne Fillet

Abstract readReview
In one paragraph

Review in Journal of biomedicine & biotechnology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed.

  1. The 'Omics Revolution in CHO Biology: Roadmap to Improved CHO Productivity.Methods in molecular biology (Clifton, N.J.) · 2025
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  8. Psoralen Derivatives with Enhanced Potency.Photochemistry and photobiology · 2020
    Article
  9. Review
  10. Article
  11. A Review: Proteomics in Nasopharyngeal Carcinoma.International journal of molecular sciences · 2015
    Review
  12. Article
  13. Article
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  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Muriel De BockLaboratory of Clinical Chemistry, GIGA Research, University of Liège, CHU, B36, 4000 Liège 1, Belgium.
Dominique de Seny
Marie-Alice Meuwis
Jean-Paul Chapelle
Edouard Louis
Michel Malaise
Marie-Paule Merville
Marianne Fillet

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Protein profiling using SELDI-TOF-MS has gained over the past few years an increasing interest in the field of biomarker discovery. The technology presents great potential if some parameters, such as sample handling, SELDI settings, and data analysis, are strictly controlled. Practical considerations to set up a robust and sensitive strategy for biomarker discovery are presented. This paper also reviews biological fluids generally available including a description of their peculiar properties and the preanalytical challenges inherent to sample collection and storage. Finally, some new insights for biomarker identification and validation challenges are provided.

Indexed as

BiomarkersBody FluidsHumansSpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationBiomarkers

Identifiers

PMID20029632
PMCPMC2793423

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.