The potential for xanthine oxidase inhibition in the prevention and treatment of cardiovascular and cerebrovascular disease.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.

1. A meta-analysis of the efficacy of allopurinol in reducing the incidence of myocardial infarction following coronary artery bypass grafting.BMC cardiovascular disorders · 2018
   Pooled it
2. Integration of Traditional and Metabolomics Biomarkers Identifies Prognostic Metabolites for Predicting Responsiveness to Nutritional Intervention against Oxidative Stress and Inflammation.Nutrients · 2017
   Trial
3. The Effect of High-dose Allopurinol Pretreatment on Inflammatory Biomarkers and Post-revascularization Coronary Blood Flow in Non-STEMI Patients: A Randomized Double Blind Clinical Trial.ARYA atherosclerosis · 2023
   Article
4. Effect of Normobaric Hypoxia on Alterations in Redox Homeostasis, Nitrosative Stress, Inflammation, and Lysosomal Function following Acute Physical Exercise.Oxidative medicine and cellular longevity · 2022
   Article
5. Combination of Uric Acid and Pro-Inflammatory Cytokines in Discriminating Patients with Gout from Healthy Controls.Journal of inflammation research · 2022
   Article
6. Left Ventricular Hypertrophy in Diabetic Cardiomyopathy: A Target for Intervention.Frontiers in cardiovascular medicine · 2021
   Review
7. Oxidative Stress and New Pathogenetic Mechanisms in Endothelial Dysfunction: Potential Diagnostic Biomarkers and Therapeutic Targets.Journal of clinical medicine · 2020
   Review
8. Influence of ferulic acid consumption in ameliorating the cadmium-induced liver and renal oxidative damage in rats.Environmental science and pollution research international · 2019
   Article
9. Allopurinol and the risk of ventricular arrhythmias in the elderly: a study using US Medicare data.BMC medicine · 2017
   Article
10. Uric acid is a risk factor for ischemic stroke and all-cause mortality in the general population: a gender specific analysis from The Tromsø Study.BMC cardiovascular disorders · 2013
    Article
11. 3,4-Dihydroxy-5-nitrobenzaldehyde (DHNB) is a potent inhibitor of xanthine oxidase: a potential therapeutic agent for treatment of hyperuricemia and gout.Biochemical pharmacology · 2013
    Article
12. Metabolic effects of mulberry leaves: exploring potential benefits in type 2 diabetes and hyperuricemia.Evidence-based complementary and alternative medicine : eCAM · 2013
    Article
13. Uric acid: a starring role in the intricate scenario of metabolic syndrome with cardio-renal damage?Internal and emergency medicine · 2012
    Review
14. Urate: a novel biomarker of Parkinson's disease risk, diagnosis and prognosis.Biomarkers in medicine · 2010
    Review

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

Authors and funding

3 authors at 1 institution in 1 country.

Funding

No grant is acknowledged in the PubMed record.

Abstract