Evidence map›Paper›PMID 20029384›Full record

SynthesisThe pharmacogenomics journal2010

Effect of dopamine D3 receptor gene polymorphisms and clozapine treatment response: exploratory analysis of nine polymorphisms and meta-analysis of the Ser9Gly variant.

R Hwang, C Zai, A Tiwari, D J Müller, M J Arranz, A G Morris, P J McKenna, J Munro, S G Potkin, J A Lieberman and 2 more

Abstract readMeta-AnalysisMulticenter Study
PubMed Publisher
In one paragraph

Synthesis in The pharmacogenomics journal, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Trial
  6. Article
  7. Review
  8. Article
  9. Review
  10. Pharmacogenetics of Antipsychotic Treatment in Schizophrenia.Methods in molecular biology (Clifton, N.J.) · 2022
    Article
  11. Genetic Testing for Antipsychotic Pharmacotherapy: Bench to Bedside.Behavioral sciences (Basel, Switzerland) · 2021
    Review
  12. Article
  13. Article
  14. Review
  15. Review
  16. The role of genetics and genomics in clinical psychiatry.Dialogues in clinical neuroscience · 2018
    Review
  17. Review
  18. Article
  19. Review
  20. Association study betweenNeuropsychiatric disease and treatment · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

R HwangNeurogenetics Section, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada.
C Zai
A Tiwari
D J Müller
M J Arranz
A G Morris
P J McKenna
J Munro
S G Potkin
J A Lieberman
H Y Meltzer
J L Kennedy

Funding

Canadian Institutes of Health Research
6 · The paper itself

Abstract

D2 blockade has been implicated in having a central role in antipsychotic response. However, treatment refractoriness, in spite of complete D2 blockade, as well as the efficacy of clozapine (CLZ) in a portion of this patient population, indicates the involvement of other factors as well. Several lines of evidence suggest a role for D3. Furthermore, an earlier meta-analysis by Jönsson et al. (2003) (n=233) suggested a role for genetic variation in the D3 gene. Relevant to this study, Jönsson et al. found the Ser allele of the D3 serine-to-glycine substitution at amino acid position 9 (Ser9Gly) polymorphism to be associated with worse CLZ response compared with the Gly allele. In this study, we attempt to validate these findings by performing a meta-analysis in a much larger sample (n=758). Eight other variants were also tested in our own sample to explore the possible effect of other regions of the gene. We report a negative but consistent trend across individual studies in our meta-analysis for the DRD3 Ser allele and poor CLZ response. A possible minor role for this single-nucleotide polymorphism cannot be disregarded, as our sample size may have been insufficient. Other DRD3 variants and haplotypes of possible interest were also identified for replication in future studies.

Indexed as

AdultAmino Acid SubstitutionAntipsychotic AgentsBlack or African AmericanClozapineFemaleHaplotypesHumansLinkage DisequilibriumMalePolymorphism, Single NucleotideReceptors, Dopamine D3SchizophreniaWhite PeopleAntipsychotic AgentsClozapineReceptors, Dopamine D3

Identifiers

PMID20029384

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.