Trial reportAJR. American journal of roentgenology2010
Patient characteristics as predictors of image quality and diagnostic accuracy of MDCT compared with conventional coronary angiography for detecting coronary artery stenoses: CORE-64 Multicenter International Trial.
Trial report in AJR. American journal of roentgenology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 3 syntheses or guidelines pooled it, 112 citations in OpenAlex.
- Diagnosis of obstructive coronary artery disease using computed tomography angiography in patients with stable chest pain depending on clinical probability and in clinically important subgroups: meta-analysis of individual patient data.BMJ (Clinical research ed.) · 2019Pooled it
- Diagnostic performance of coronary CT angiography for stenosis detection according to calcium score: systematic review and meta-analysis.European radiology · 2012Pooled it
- Influence of coronary artery disease prevalence on predictive values of coronary CT angiography: a meta-regression analysis.European radiology · 2011Pooled it
- Reduction of cardiac motion artifact in step-and-shoot coronary CT angiography with third-generation as compared with second-generation dual-source CT scanners.Diagnostic and interventional radiology (Ankara, Turkey) · 2021Trial
- Correlation between low tube voltage in dual source CT coronary artery imaging with image quality and radiation dose.Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban · 2014Trial
- Predictors of inaccurate coronary arterial stenosis assessment by CT angiography.JACC. Cardiovascular imaging · 2013Trial
- Application of low-dose "one-stop" myocardial computed tomography perfusion imaging in coronary artery disease.Quantitative imaging in medicine and surgery · 2026Article
- Predictors of Diagnostic Inaccuracy of Detecting Coronary Artery Stenosis by Preprocedural CT Angiography in Patients Prior to Transcatheter Aortic Valve Implantation.Diagnostics (Basel, Switzerland) · 2025Article
- [The challenging patient-recommendations and solutions].Radiologie (Heidelberg, Germany) · 2024Review
- The Effect of Severe Coronary Calcification on Diagnostic Performance of Computed Tomography-Derived Fractional Flow Reserve Analyses in People with Coronary Artery Disease.Diagnostics (Basel, Switzerland) · 2024Article
- Impact of coronary CT image quality on the accuracy of the FFREuropean radiology · 2024Article
- [Assessment of Coronary Stenosis Using Coronary CT Angiography in Patients with High Calcium Scores: Current Limitations and Future Perspectives].Journal of the Korean Society of Radiology · 2024Review
- Cardiac Computed Tomography Angiography in the Evaluation of Coronary Artery Disease: An Interventional Perspective.Journal of the Society for Cardiovascular Angiography & Interventions · 2024Review
- CT annulus sizing prior to transcatheter aortic valve replacement (TAVR): evaluation of free-breathing versus breath-holding acquisition.European radiology · 2023Article
- Pre-screening for non-diagnostic coronary computed tomography angiography.European heart journal. Imaging methods and practice · 2023Article
- Cardiac CT blooming artifacts: clinical significance, root causes and potential solutions.Visual computing for industry, biomedicine, and art · 2022Review
- Prospective Study of Low-Radiation and Low-Iodine Dose Aortic CT Angiography in Obese and Non-Obese Patients: Image Quality and Impact of Patient Characteristics.Diagnostics (Basel, Switzerland) · 2022Article
- Clinical applications of cardiac computed tomography: a consensus paper of the European Association of Cardiovascular Imaging-part I.European heart journal. Cardiovascular Imaging · 2022Article
- Article
- Sequential Strategy Including FFRJournal of clinical medicine · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 4 institutions in 4 countries.
Funding
Abstract
objectiveThe purpose of the study was to investigate patient characteristics associated with image quality and their impact on the diagnostic accuracy of MDCT for the detection of coronary artery stenosis. MATERIALS AND
methodsTwo hundred ninety-one patients with a coronary artery calcification (CAC) score of <or=600 Agatston units (214 men and 77 women; mean age, 59.3+/-10.0 years [SD]) were analyzed. An overall image quality score was derived using an ordinal scale. The accuracy of quantitative MDCT to detect significant (>or=50%) stenoses was assessed using quantitative coronary angiography (QCA) per patient and per vessel using a modified 19-segment model. The effect of CAC, obesity, heart rate, and heart rate variability on image quality and accuracy were evaluated by multiple logistic regression. Image quality and accuracy were further analyzed in subgroups of significant predictor variables. Diagnostic analysis was determined for image quality strata using receiver operating characteristic (ROC) curves.
resultsIncreasing body mass index (BMI) (odds ratio [OR]=0.89, p<0.001), increasing heart rate (OR=0.90, p<0.001), and the presence of breathing artifact (OR=4.97, p<or=0.001) were associated with poorer image quality whereas sex, CAC score, and heart rate variability were not. Compared with examinations of white patients, studies of black patients had significantly poorer image quality (OR=0.58, p=0.04). At a vessel level, CAC score (10 Agatston units) (OR=1.03, p=0.012) and patient age (OR=1.02, p=0.04) were significantly associated with the diagnostic accuracy of quantitative MDCT compared with QCA. A trend was observed in differences in the areas under the ROC curves across image quality strata at the vessel level (p=0.08).
conclusionImage quality is significantly associated with patient ethnicity, BMI, mean scan heart rate, and the presence of breathing artifact but not with CAC score at a patient level. At a vessel level, CAC score and age were associated with reduced diagnostic accuracy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.