ArticleAJR. American journal of roentgenology2010
Quantification of muscle choline concentrations by proton MR spectroscopy at 3 T: technical feasibility.
Article in AJR. American journal of roentgenology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 46 citations in OpenAlex.
- Characterization of peripheral nerve sheath tumors with 3T proton MR spectroscopy.AJNR. American journal of neuroradiology · 2014Trial
- Multiparametric magnetic resonance imaging, spectroscopy and multinuclear (²³Na) imaging monitoring of preoperative chemotherapy for locally advanced breast cancer.Academic radiology · 2010Trial
- Multiparametric quantitative magnetic resonance imaging of skeletal muscle in CKD.American journal of physiology. Renal physiology · 2025Article
- Detection of electrostatic molecular binding using the water proton signal.Magnetic resonance in medicine · 2022Article
- In VivoJournal of magnetic resonance imaging : JMRI · 2021Article
- Article
- Quantitative MRI Musculoskeletal Techniques: An Update.AJR. American journal of roentgenology · 2019Review
- Global brain metabolic quantification with whole-head proton MRS at 3 T.NMR in biomedicine · 2017Article
- Myocardial Metabolic Abnormality in a Primary Left Atrial Rhabdomyosarcoma: Localized 1H MR Spectroscopy.Iranian journal of radiology : a quarterly journal published by the Iranian Radiological Society · 2015Article
- Role of MR spectroscopy in musculoskeletal imaging.The Indian journal of radiology & imaging · 2014Article
- Proton magnetic resonance spectroscopy of skeletal muscle: a comparison of two quantitation techniques.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2014Article
- Influence of calcium on choline measurements by 1H MR spectroscopy of thigh muscles.European radiology · 2014Article
- Schwannoma in neurofibromatosis type 1: a pitfall for detecting malignancy by metabolic imaging.Skeletal radiology · 2013Article
- Musculoskeletal tumors: how to use anatomic, functional, and metabolic MR techniques.Radiology · 2012Review
- Advances in musculoskeletal MRI: technical considerations.Journal of magnetic resonance imaging : JMRI · 2012Review
- Quantification of choline concentration following liver cell apoptosis using 1H magnetic resonance spectroscopy.World journal of gastroenterology · 2012Article
- Proton MR spectroscopy in metabolic assessment of musculoskeletal lesions.AJR. American journal of roentgenology · 2012Review
- Therapeutic response in musculoskeletal soft tissue sarcomas: evaluation by MRI.NMR in biomedicine · 2011Review
- Article
- A feasibility study of quantitative molecular characterization of musculoskeletal lesions by proton MR spectroscopy at 3 T.AJR. American journal of roentgenology · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveThe quantification of choline in musculoskeletal tissues has several potential uses, including characterizing malignancy, but has not been previously achievable. We present a method of measuring the absolute concentration of choline by proton MR spectroscopy (MRS) in skeletal muscle at 3 T. MATERIALS AND
methodsAt 3 T, choline measurements were performed in phantoms and healthy volunteers using proton MRS (point-resolved spectroscopy sequence [PRESS]; TR/TE, 2,000/135). In vitro choline concentrations were measured in three phantom solutions (10, 5, 1.25 mmol). Choline T1 and T2 relaxation times were measured in the muscles of five healthy subjects. In vivo choline concentrations were measured using water as an internal reference and average T1 and T2 relaxation times in 20 muscle locations (quadriceps, hamstring, adductor) of seven healthy subjects (four men, three women). Descriptive statistics are reported.
resultsIn vitro, the average measured choline concentrations of the 10-, 5-, and 1.25-mmol solutions were 9.91, 5.03, and 1.22 mmol, respectively. In vivo, the average T1 and T2 relaxation times of choline were 1,372+/-57 (SD) and 134+/-11 milliseconds, respectively. The average choline concentrations in the quadriceps and hamstring muscles were 10.0+/-0.4 (SD) and 8.0+/-2.9 mmol/kg. Interindividual variation existed in the choline concentrations (quadriceps range, 6.7-13 mmol/kg), but there was little variation by patient sex.
conclusionIn the musculoskeletal system, the measurement of choline concentration by proton MRS at 3 T is feasible using water as an internal reference. These data provide a quantitative basis for future investigations of metabolite concentrations in normal and diseased musculoskeletal tissues.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.