ArticleThe Plant cell2009
Orthologs of the class A4 heat shock transcription factor HsfA4a confer cadmium tolerance in wheat and rice.
Article in The Plant cell, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 113 papers.
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113 citing papers in PubMed.
- Adaptation of morphological traits and anatomy structure related to Cd spatial distribution in wild rice Oryza officinalis and Oryza rufipogon roots.BMC plant biology · 2026Article
- Characterization of the Differential Tolerance of TwoPlants (Basel, Switzerland) · 2026Article
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- Leveraging multi-omics tools to comprehend responses and tolerance mechanisms of heavy metals in crop plants.Functional & integrative genomics · 2024Review
- Cadmium toxicity: its' uptake and retaliation by plant defence system and ja signaling.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2024Review
- The Uptake, Transfer, and Detoxification of Cadmium in Plants and Its Exogenous Effects.Cells · 2024Review
- Genome-wide identification, classification and expression analysis of the heat shock transcription factor family in Garlic (Allium sativum L.).BMC plant biology · 2024Article
- A LlWRKY33-LlHSFA4-LlCAT2 module confers resistance toHorticulture research · 2024Article
- Zinc accumulation in Atriplex lentiformis is driven by plant genes and the soil microbiome.The Science of the total environment · 2023Article
- Transcriptome Analysis Reveals the Stress Tolerance Mechanisms of Cadmium inPlants (Basel, Switzerland) · 2023Article
- The Effect of Cadmium on Plants in Terms of the Response of Gene Expression Level and Activity.Plants (Basel, Switzerland) · 2023Review
- Conserved and variable heat stress responses of the Heat Shock Factor transcription factor family in maize andPlant direct · 2023Article
- Transcriptional Regulatory Network of Plant Cadmium Stress Response.International journal of molecular sciences · 2023Review
- The Early Oxidative Stress Induced by Mercury and Cadmium Is Modulated by Ethylene inAntioxidants (Basel, Switzerland) · 2023Article
- Genetic Regulation Mechanism of Cadmium Accumulation and Its Utilization in Rice Breeding.International journal of molecular sciences · 2023Review
- Genome-wide analysis of HSF family and overexpression ofFrontiers in plant science · 2023Article
- Wheat Selenium-binding protein TaSBP-A enhances cadmium tolerance by decreasing free CdFrontiers in plant science · 2023Article
- Multi-Omics Uncover the Mechanism of Wheat under Heavy Metal Stress.International journal of molecular sciences · 2022Review
- OsNAC15 Regulates Tolerance to Zinc Deficiency and Cadmium by Binding toInternational journal of molecular sciences · 2022Article
53 more citing papers are in PubMed but not listed here.
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8 authors.
Funding
Abstract
Cadmium (Cd) is a widespread soil pollutant; thus, the underlying molecular controls of plant Cd tolerance are of substantial interest. A screen for wheat (Triticum aestivum) genes that confer Cd tolerance to a Cd hypersensitive yeast strain identified Heat shock transcription factor A4a (HsfA4a). Ta HsfA4a is most similar to the class A4 Hsfs from monocots. The most closely related rice (Oryza sativa) homolog, Os HsfA4a, conferred Cd tolerance in yeast, as did Ta HsfA4a, but the second most closely related rice homolog, Os HsfA4d, did not. Cd tolerance was enhanced in rice plants expressing Ta HsfA4a and decreased in rice plants with knocked-down expression of Os HsfA4a. An analysis of the functional domain using chimeric proteins constructed from Ta HsfA4a and Os HsfA4d revealed that the DNA binding domain (DBD) of HsfA4a is critical for Cd tolerance, and within the DBD, Ala-31 and Leu-42 are important for Cd tolerance. Moreover, Ta HsfA4a-mediated Cd resistance in yeast requires metallothionein (MT). In the roots of wheat and rice, Cd stress caused increases in HsfA4a expression, together the MT genes. Our findings thus suggest that HsfA4a of wheat and rice confers Cd tolerance by upregulating MT gene expression in planta.
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