ArticleEvidence-based complementary and alternative medicine : eCAM2011
Analyzing Cytotoxic and Apoptogenic Properties of Scutellaria litwinowii Root Extract on Cancer Cell Lines.
Article in Evidence-based complementary and alternative medicine : eCAM, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Neobaicalein, a flavonoid from theIranian journal of basic medical sciences · 2023Article
- A Review of Medicinal Plants of the Himalayas with Anti-Proliferative Activity for the Treatment of Various Cancers.Cancers · 2022Review
- Auraptene-induced cytotoxicity mechanisms in human malignant glioblastoma (U87) cells: role of reactive oxygen species (ROS).EXCLI journal · 2019Article
- Cytotoxic and apoptotic effects of root extract and tanshinones isolated fromIranian journal of basic medical sciences · 2017Article
- The Analgesic and Antineuroinflammatory Effect of Baicalein in Cancer-Induced Bone Pain.Evidence-based complementary and alternative medicine : eCAM · 2015Article
- In-vitro Evaluation of Cytotoxic and Apoptogenic Properties of Sophora Pachycarpa.Iranian journal of pharmaceutical research : IJPR · 2014Article
- Anti-tumor Activity of Ferulago angulata Boiss. Extract in Gastric Cancer Cell Line via Induction of Apoptosis.Iranian journal of pharmaceutical research : IJPR · 2014Article
- Apoptosis Induction of Salvia chorassanica Root Extract on Human Cervical Cancer Cell Line.Iranian journal of pharmaceutical research : IJPR · 2013Article
- Growth Inhibition and Apoptosis Induction of Salvia chloroleuca on MCF-7 Breast Cancer Cell Line.Iranian journal of pharmaceutical research : IJPR · 2013Article
- The potential anticancer activity of extracts derived from the roots ofMolecular and clinical oncology · 2013Article
- Protective Effect of Scutellaria litwinowii Extract on Serum/Glucose-Deprived Cultured PC12 Cells and Determining the Role of Reactive Oxygen Species.Journal of toxicology · 2012Article
- Thujone-Rich Fraction of Thuja occidentalis Demonstrates Major Anti-Cancer Potentials: Evidences from In Vitro Studies on A375 Cells.Evidence-based complementary and alternative medicine : eCAM · 2011Article
- Medicinal plants used as antitumor agents in Brazil: an ethnobotanical approach.Evidence-based complementary and alternative medicine : eCAM · 2011Article
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Authors and funding
5 authors.
Funding
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Abstract
The Scutellaria species (Lamiaceae) is used as a source of flavonoids to treat a variety of diseases in traditional medicine. In spite of many reports about the cytotoxic and antitumor effects of some species of this genus, anticancer researches on one of the Iranian species S. litwinowii have not yet been conducted. The cytotoxic properties of total methanol extract of S. litwinowii and its fractions were investigated on different cancer cell lines including AGS, HeLa, MCF-7, PC12 and NIH 3T3. Meanwhile, the role of apoptosis in this toxicity was explored. The cells were cultured in DMEM medium and incubated with different concentrations of herb plant extracts. Cell viability was quantitated by MTT assay. Apoptotic cells were determined using propidium iodide staining of DNA fragmentation by flow cytometry (sub-G1 peak). Scutellaria litwinowii inhibited the growth of malignant cells in a dose-dependent manner. Among solvent fractions of S. litwinowii, the methylene chloride fraction was found to be more toxic compared to other fractions. The IC(50) values of this fraction against AGS, HeLa, MCF-7 and PC12 cell lines after 24 h were determined, 121.2 ± 3.1, 40.9 ± 2.5, 115.9 ± 3.5 and 64.5 ± 3.4 μg/ml, respectively. Scutellaria litwinowii induced a sub-G1 peak in the flow cytometry histogram of treated cells compared to control cells indicating that apoptotic cell death is involved in S. litwinowii toxicity. Scutellaria litwinowii exerts cytotoxic and proapototic effects in a variety of malignant cell lines and could be considered as a potential chemotherapeutic agent in cancer treatment.
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Registered trials
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