ArticleBMC medical genetics2009
A tagging SNP in INSIG2 is associated with obesity-related phenotypes among Samoans.
Article in BMC medical genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 18 citations in OpenAlex.
- The gene-gene interaction of INSIG-SCAP-SREBP pathway on the risk of obesity in Chinese children.BioMed research international · 2014Trial
- The Microbiota and Evolution of Obesity.Endocrine reviews · 2025Review
- INSIG2 variants, dietary patterns and metabolic risk in Samoa.European journal of clinical nutrition · 2013Article
- Genetic association of SNPs in the FTO gene and predisposition to obesity in Malaysian Malays.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2012Article
- Epigenetics, and human biology and health responses to modernization in the Samoan archipelago.Collegium antropologicum · 2012Article
- Testing the thrifty gene hypothesis: the Gly482Ser variant in PPARGC1A is associated with BMI in Tongans.BMC medical genetics · 2011Article
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Authors and funding
9 authors at 6 institutions in 3 countries.
Funding
Abstract
backgroundA genome wide association study found significant association of a sequence variant, rs7566605, in the insulin-induced gene 2 (INSIG2) with obesity. However, the association remained inconclusive in follow-up studies. We tested for association of four tagging SNPs (tagSNPs) including this variant with body mass index (BMI) and abdominal circumference (ABDCIR) in the Samoans of the Western Pacific, a population with high levels of obesity.
methodsWe studied 907 adult Samoan participants from a longitudinal study of adiposity and cardiovascular disease risk in two polities, American Samoa and Samoa. Four tagSNPs were identified from the Chinese HapMap database based on pairwise r2 of >or=0.8 and minor allele frequency of >or=0.05. Genotyping was performed using the TaqMan assay. Tests of association with BMI and ABDCIR were performed under the additive model.
resultsWe did not find association of rs7566605 with either BMI or ABDCIR in any group of the Samoans. However, the most distally located tagSNPs in Intron 3 of the gene, rs9308762, showed significant association with both BMI (p-value 0.024) and ABDCIR (p-value 0.009) in the combined sample and with BMI (p-value 0.038) in the sample from Samoa.
conclusionAlthough rs7566605 was not significantly associated with obesity in our study population, we can not rule out the involvement of INSIG2 in obesity related traits as we found significant association of another tagSNP in INSIG2 with both BMI and ABDCIR. This study suggests the importance of comprehensive assessment of sequence variants within a gene in association studies.
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