ArticleBMC infectious diseases2009
Diagnostic and prognostic value of procalcitonin among febrile critically ill patients with prolonged ICU stay.
Article in BMC infectious diseases, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07211620 (KInetics of Procalcitonin to Reduce Unnecessary aNtibiotic Use), which is not on this map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
KInetics of Procalcitonin to Reduce Unnecessary aNtibiotic Use (KIPRUN) - Protocol for a Multi-center, Randomized, Superiority Trial to Compare the Efficacy and Safety of Procalcitonin Kinetics-guided and Absolute Procalcitonin Value-guided Antibiotic Initiation in Reducing Unnecessary Antibiotic Therapy in Critically Ill Patients
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Inflammatory Biomarkers Are Inaccurate Indicators of Bacterial Infection on Admission in Patients With Acute Exacerbation of Chronic Obstructive Pulmonary Disease-A Systematic Review and Diagnostic Accuracy Network Meta-Analysis.Frontiers in medicine · 2021Pooled it
- Article
- Article
- Diagnostic and prognostic value of MR-pro ADM, procalcitonin, and copeptin in sepsis.Open medicine (Warsaw, Poland) · 2023Article
- Clinical value of procalcitonin in critically ill patients infected by SARS-CoV-2.The American journal of emergency medicine · 2021Observational
- Review
- Interpreting procalcitonin in patients undergoing hemodialysis: a reliable or a misleading marker?Internal and emergency medicine · 2021Article
- Diagnostic Accuracy of Procalcitonin for Differentiating Bacteraemic Gram-Negative Sepsis from Gram-Positive Sepsis.Turkish journal of anaesthesiology and reanimation · 2018Article
- Checking procalcitonin suitability for prognosis and antimicrobial therapy monitoring in burn patients.Burns & trauma · 2018Article
- Value of evaluating procalcitonin kinetics in diagnosis of infections in patients undergoing laparoscopic radical cystectomy.Medicine · 2017Article
- Biomarkers for diagnosis of sepsis in patients with systemic inflammatory response syndrome: a systematic review and meta-analysis.SpringerPlus · 2016Article
- Delta Procalcitonin Is a Better Indicator of Infection Than Absolute Procalcitonin Values in Critically Ill Patients: A Prospective Observational Study.Journal of immunology research · 2016Observational
- Use of a Combination Biomarker Algorithm To Identify Medical Intensive Care Unit Patients with Suspected Sepsis at Very Low Likelihood of Bacterial Infection.Antimicrobial agents and chemotherapy · 2015Article
- Sepsis: From Pathophysiology to Individualized Patient Care.Journal of immunology research · 2015Review
- Diagnostic value of serum leptin and a promising novel diagnostic model for sepsis.Experimental and therapeutic medicine · 2014Article
- Article
- Procalcitonin and procalcitonin kinetics for diagnosis and prognosis of intravascular catheter-related bloodstream infections in selected critically ill patients: a prospective observational study.BMC infectious diseases · 2012Article
- Acute phase proteins and white blood cell levels for prediction of infectious complications in status epilepticus.Critical care (London, England) · 2011Article
- Top stories of 2009.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2010Article
- Comparison of serum procalcitonin level with erythrocytes sedimentation rate, C-reactive protein, white blood cell count, and blood culture in the diagnosis of bacterial infections in patients hospitalized in Motahhari hospital of Urmia (2016).Journal of advanced pharmaceutical technology & researchArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundProcalcitonin (PCT) has been proposed as a diagnostic and prognostic sepsis marker, but has never been validated in febrile patients with prolonged ICU stay.
methodsPatients were included in the study provided they were hospitalised in the ICU for > 10 days, were free of infection and presented a new episode of SIRS, with fever >38 degrees C being obligatory. Fifty patients fulfilled the above criteria. PCT was measured daily during the ICU stay. The primary outcome was proven infection.
resultsTwenty-seven out of 50 patients were diagnosed with infection. Median PCT on the day of fever was 1.18 and 0.17 ng/ml for patients with and without proven infections (p < 0.001). The area under the curve for PCT was 0.85 (95% CI; 0.71-0.93), for CRP 0.65 (0.46-0.78) and for WBC 0.68 (0.49-0.81). A PCT level of 1 ng/mL yielded a negative predictive value of 72% for the presence of infection, while a PCT of 1.16 had a specificity of 100%. A two-fold increase of PCT between fever onset and the previous day was associated with proven infection (p 0.001) (OR = 8.55; 2.4-31.1), whereas a four-fold increase of PCT of any of the 6 preceding days was associated with a positive predictive value exceeding 69.65%. A PCT value less than 0.5 ng/ml on the third day after the advent of fever was associated with favorable survival (p 0.01).
conclusionThe reported data support that serial serum PCT may be a valuable diagnostic and prognostic marker in febrile chronic critically ill patients.
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