ArticleBMC infectious diseases2009
Co-infection by human immunodeficiency virus type 1 (HIV-1) and human T cell leukemia virus type 1 (HTLV-1): does immune activation lead to a faster progression to AIDS?
Article in BMC infectious diseases, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Pooled it
- Article
- HTLV-1 Coinfection among Patients Attending a Large HIV Treatment Centre in Trinidad.Microorganisms · 2022Article
- Dynamics of HIV-1/HTLV-I Co-Infection Model with Humoral Immunity and Cellular Infection.Viruses · 2022Article
- Human T-Lymphotropic virus type 1 and human immunodeficiency virus co-infection in rural Gabon.PloS one · 2022Article
- Article
- Distribution of Human Immunodeficiency Virus and Human T-Leukemia Virus Co-infection in Bahia, Brazil.Frontiers in medicine · 2021Article
- Article
- Neurological Aspects of HIV-1/HTLV-1 and HIV-1/HTLV-2 Coinfection.Pathogens (Basel, Switzerland) · 2020Review
- HTLV-1, ATLL, severe hypercalcaemia and HIV-1 co-infection: an overview.The Pan African medical journal · 2018Review
- Assessment of WHO criteria for identifying ART treatment failure in Vietnam from 2007 to 2011.PloS one · 2017Article
- CD4(+)CD25(High) Treg cells in HIV/HTLV co-infected patients with neuropathy: high expression of Alpha4 integrin and lower expression of Foxp3 transcription factor.BMC immunology · 2015Article
- Molecular Detection and Clinical Implications of HTLV-1 Infections among Antiretroviral Therapy-Naïve HIV-1-Infected Individuals in Abuja, Nigeria.Virology : research and treatment · 2015Article
- Predictive factors of HTLV1-HIV coinfections in French Guiana.The American journal of tropical medicine and hygiene · 2013Article
- Induction of CC-chemokines with antiviral function in macrophages by the human T lymphotropic virus type 2 transactivating protein, Tax2.Viral immunology · 2013Article
- Altered frequency and phenotype of CD4+ forkhead box protein 3+ T cells and its association with autoantibody production in human immunodeficiency virus-infected paediatric patients.Clinical and experimental immunology · 2012Article
- Alterations in T cell subsets in human immunodeficiency virus-infected adults with co-infections in southern Mozambique.The American journal of tropical medicine and hygiene · 2011Article
- HIV and HTLV-1 coinfection: the need to initiate antiretroviral therapy.Journal of the International Association of Providers of AIDS CareArticle
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRecent data have shown that HTLV-1 is prevalent among HIV positive patients in Mozambique, although the impact of HTLV-1 infection on HIV disease progression remains controversial. Our aim was to determine the phenotypic profile of T lymphocytes subsets among Mozambican patients co-infected by HIV and HTLV-1.
methodsWe enrolled 29 patients co-infected by HTLV-1 and HIV (co-infected), 59 patients mono-infected by HIV (HIV) and 16 healthy controls (HC), respectively.For phenotypic analysis, cells were stained with the following fluorochrome-labeled anti-human monoclonal antibodies CD4-APC, CD8-PerCP, CD25-PE, CD62L-FITC, CD45RA-FITC. CD45RO-PE, CD38-PE; being analysed by four-colour flow cytometry.
resultsWe initially found that CD4+ T cell counts were significantly higher in co-infected, as compared to HIV groups. Moreover, CD4+ T Lymphocytes from co-infected patients presented significantly higher levels of CD45RO and CD25, but lower levels of CD45RA and CD62L, strongly indicating that CD4+ T cells are more activated under HTLV-1 plus HIV co-infection.
conclusionOur data indicate that HTLV-1/HIV co-infected patients progress with higher CD4+ T cell counts and higher levels of activation markers. In this context, it is conceivable that in co-infected individuals, these higher levels of activation may account for a faster progression to AIDS.
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Registered trials
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