ArticleWorld journal of gastroenterology2009
Reduced normogastric electrical activity associated with emesis: a telemetric study in ferrets.
Article in World journal of gastroenterology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Review
- Care, management, and use of ferrets in biomedical research.Laboratory animal research · 2024Review
- Isoflurane anesthesia suppresses gastric myoelectric power in the ferret.Neurogastroenterology and motility · 2024Article
- Article
- Prediction of gastrointestinal functional state based on myoelectric recordings utilizing a deep neural network architecture.PloS one · 2023Article
- Mechanisms of Chemotherapy-Induced Neurotoxicity.Frontiers in pharmacology · 2022Review
- Insights Into Acute and Delayed Cisplatin-Induced Emesis From a Microelectrode Array, Radiotelemetry and Whole-Body Plethysmography Study ofFrontiers in pharmacology · 2021Article
- Sulprostone-Induced Gastric Dysrhythmia in the Ferret: Conventional and Advanced Analytical Approaches.Frontiers in physiology · 2020Article
- Article
- Article
- What is nausea? A historical analysis of changing views.Autonomic neuroscience : basic & clinical · 2017Review
- Differential hypoglycaemic, anorectic, autonomic and emetic effects of the glucagon-like peptide receptor agonist, exendin-4, in the conscious telemetered ferret.Journal of translational medicine · 2014Article
- Measuring the nausea-to-emesis continuum in non-human animals: refocusing on gastrointestinal vagal signaling.Experimental brain research · 2014Review
- Post-anesthesia vomiting: impact of isoflurane and morphine on ferrets and musk shrews.Physiology & behavior · 2012Article
- Computerized detection and analysis of cancer chemotherapy-induced emesis in a small animal model, musk shrew.Journal of neuroscience methods · 2011Article
- Behavioral patterns associated with chemotherapy-induced emesis: a potential signature for nausea in musk shrews.Frontiers in neuroscience · 2011Article
- The involvement of TRPV1 in emesis and anti-emesis.Temperature (Austin, Tex.)Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
aimTo characterize the gastric myoelectric activity (GMA) and intra-abdominal pressure changes induced by emetic stimuli (apomorphine and cisplatin) in the ferret.
methodsGMA and intra-abdominal pressure were recorded in conscious, unrestrained ferrets surgically implanted with radiotelemetry transmitters. Animals were challenged with apomorphine (0.25 mg/kg sc) and cisplatin (10 mg/kg ip), and the emetic response was quantified via direct observation and intra-abdominal pressure recording for 1 h and 4 h, respectively. The GMA was analyzed by spectral analysis; the parameters used to characterize the GMA were the dominant frequency (DF) and the repartition of spectral power in the bradygastric, normogastric and tachygastric frequency ranges.
resultsRetches were identified on the intra-abdominal pressure trace as peaks 0.30 +/- 1.01 s in duration and 59.57 +/- 2.74 mmHg in amplitude, vomit peaks were longer (0.82 +/- 0.06 s, P < 0.01) and reached a higher pressure (87.73 +/- 8.12 mmHg, P < 0.001). The number of retches and vomits quantified via direct observation [apomorphine: 65.5 +/- 11.8 retches + vomits (R+V), cisplatin: 202.6 +/- 64.1 R+V] and intra-abdominal pressure (apomorphine: 68.3 +/- 13.7 R+V, n = 8; cisplatin: 219.0 +/- 69.2 R+V, n = 8) were correlated (r = 0.97, P < 0.0001) and the timing of emesis was consistent between the 2 methods. Apomorphine induced a decrease in normogastria from 45.48% +/- 4.35% to 36.70 +/- 4.34% (n = 8, P < 0.05) but the DF of the slow waves was not changed [8.95 +/- 0.25 counts/min (cpm) vs 8.68 +/- 0.35 cpm, n = 8, P > 0.05]. Cisplatin induced a decrease in normogastria from 55.83% +/- 4.30% to 29.22% +/- 5.16% and an increase in bradygastria from 14.28% +/- 2.32% to 31.19% +/- 8.33% (n = 8, P < 0.001) but the DF (9.14 +/- 0.13 cpm) remained unchanged (P > 0.05). The GMA changes induced by cisplatin preceded the emetic response as normogastria was reduced for 1 h before the onset of emesis (57.61% +/- 5.66% to 39.91% +/- 5.74%, n = 6, P < 0.05). Peri-emesis analysis revealed that the GMA was significantly disturbed during and immediately after, but not immediately before, the emetic episodes.
conclusionThe induction of emesis is reliably associated with a disrupted GMA, but changes may also occur prior to and following the emetic response.
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