ArticleGenetics2010
Natural variation in odorant recognition among odorant-binding proteins in Drosophila melanogaster.
Article in Genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 40 citations in OpenAlex.
- Chromosome-level genome assembly of the synanthropic fly Chrysomya megacephala: insights into oviposition location.BMC genomics · 2025Article
- Experimental Evolution Induced by Maternal Post-copulatory Factors in Drosophila.Behavior genetics · 2025Article
- Mechanisms of Variability Underlying Odor-Guided Locomotion.Frontiers in behavioral neuroscience · 2022Review
- Molecular basis of resistance to organophosphate insecticides in the New World screw-worm fly.Parasites & vectors · 2020Article
- Evidence of peripheral olfactory impairment in the domestic silkworms: insight from the comparative transcriptome and population genetics.BMC genomics · 2018Article
- The road less traveled: from genotype to phenotype in flies and humans.Mammalian genome : official journal of the International Mammalian Genome Society · 2018Article
- Artificial selection for odor-guided behavior in Drosophila reveals changes in food consumption.BMC genomics · 2017Article
- A nonrandom subset of olfactory genes is associated with host preference in the fruit flyEvolution letters · 2017Article
- Obp56h Modulates Mating Behavior in Drosophila melanogaster.G3 (Bethesda, Md.) · 2016Article
- Weak Polygenic Selection Drives the Rapid Adaptation of the Chemosensory System: Lessons from the Upstream Regions of the Major Gene Families.Genome biology and evolution · 2016Article
- Reference genes for accessing differential expression among developmental stages and analysis of differential expression of OBP genes in Anastrepha obliqua.Scientific reports · 2016Article
- The genetic basis for variation in olfactory behavior in Drosophila melanogaster.Chemical senses · 2015Article
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- Analysis of natural variation reveals neurogenetic networks for Drosophila olfactory behavior.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Genetic variation in odorant receptors contributes to variation in olfactory behavior in a natural population of Drosophila melanogaster.Chemical senses · 2012Article
- Insect olfaction from model systems to disease control.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Functional dissection of Odorant binding protein genes in Drosophila melanogaster.Genes, brain, and behavior · 2011Article
- Making scents of behavioural genetics: lessons from Drosophila.Genetics research · 2010Review
- Natural variation, functional pleiotropy and transcriptional contexts of odorant binding protein genes in Drosophila melanogaster.Genetics · 2010Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Chemical recognition is essential for survival and reproduction. Adaptive evolution has resulted in diverse chemoreceptor families, in which polymorphisms contribute to individual variation in chemosensation. To gain insights into the genetic determinants of individual variation in odorant recognition, we measured olfactory responses to two structurally similar odorants in a population of wild-derived inbred lines of Drosophila melanogaster. Odorant-binding proteins (OBPs) are the first components of the insect olfactory system to encounter odorants. Previously four single-nucleotide polymorphisms (SNPs) in the Obp99 group were associated with variation in olfactory responses to benzaldehyde. Here, we identify six different SNPs that are associated with variation in responses to a structurally similar odorant, acetophenone, in the same Obp genes. Five SNPs are in coding regions of Obp99b and Obp99d and one SNP is in the 3'-untranslated region of Obp99a (A610G). We found that the 610G allele is associated with higher response scores to acetophenone than the 610A allele, but with lower expression of Obp99a, suggesting that binding of acetophenone to Opb99a might limit rather than facilitate access to odorant receptors. Our results show that overlapping sets of OBPs contribute to odorant recognition for structurally similar odorants, but that different SNPs are associated with odorant-specific individual variation. Thus, dual olfactory recognition where OBPs regulate odorant access to receptors may enhance olfactory discrimination.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.