ArticleBiochemical and biophysical research communications2010
Distinct ONE-GC transduction modes and motifs of the odorants: Uroguanylin and CO(2).
Article in Biochemical and biophysical research communications, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 13 citations in OpenAlex.
- Multilimbed membrane guanylate cyclase signaling system, evolutionary ladder.Frontiers in molecular neuroscience · 2022Review
- Integrative Signaling Networks of Membrane Guanylate Cyclases: Biochemistry and Physiology.Frontiers in molecular neuroscience · 2016Review
- Bicarbonate and Ca(2+) Sensing Modulators Activate Photoreceptor ROS-GC1 Synergistically.Frontiers in molecular neuroscience · 2016Article
- Bicarbonate Modulates Photoreceptor Guanylate Cyclase (ROS-GC) Catalytic Activity.The Journal of biological chemistry · 2015Article
- Receptor guanylyl cyclase-G is a novel thermosensory protein activated by cool temperatures.The EMBO journal · 2015Article
- The ANF-RGC gene motif (669)WTAPELL(675) is vital for blood pressure regulation: biochemical mechanism.Biochemistry · 2013Article
- Ca(2+) modulation of ANF-RGC: new signaling paradigm interlocked with blood pressure regulation.Biochemistry · 2012Article
- A single gene target of an ETS-family transcription factor determines neuronal CO2-chemosensitivity.PloS one · 2012Article
- 657WTAPELL663 motif of the photoreceptor ROS-GC1: a general phototransduction switch.Biochemical and biophysical research communications · 2011Article
- Allosteric modification, the primary ATP activation mechanism of atrial natriuretic factor receptor guanylate cyclase.Biochemistry · 2011Article
- Physiological sensing of carbon dioxide/bicarbonate/pH via cyclic nucleotide signaling.Sensors (Basel, Switzerland) · 2011Review
- Ca(2+) sensor GCAP1: A constitutive element of the ONE-GC-modulated odorant signal transduction pathway.Biochemistry · 2010Article
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2 authors at 1 institution in 1 country.
Funding
Abstract
In a subset of the olfactory sensory neurons ONE-GC($) membrane guanylate cyclase is a central component of two odorant-dependent cyclic GMP signaling pathways. These odorants are uroguanylin and CO(2). The present study was designed to decipher the biochemical and molecular differences between these two odorant signaling mechanisms. The study shows (1) in contrast to uroguanylin, CO(2) transduction mechanism is Ca(2+)-independent. (2) CO(2) transduction site, like that of uroguanylin-neurocalcin delta, resides in the core catalytic domain, aa 880-1028, of ONE-GC. (3) The site, however, does not overlap the signature neurocalcin delta signal transduction domain, (908)LSEPIE(913). Finally, (4) this study negates the prevailing concept that CO(2) uniquely signals ONE-GC activity (Sun et al. [19]; Guo et al. [21]). It demonstrates that it also signals the activation of photoreceptor membrane guanylate cyclase ROS-GC1. These results show an additional new transduction mechanism of the membrane guanylate cyclases and broaden our understanding of the molecular mechanisms by which different odorants using a single guanylate cyclase can regulate diverse cyclic GMP signaling pathways.
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