ArticleBrain, behavior, and immunity2010
Differential sensitivity to endotoxin exposure in young and middle-age mice.
Article in Brain, behavior, and immunity, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed.
- Sex-dependent deficits in associative learning across multiple LPS doses.Physiology & behavior · 2023Article
- Article
- Testing oxygenated microbubbles via intraperitoneal and intrathoracic routes on a large pig model of LPS-induced acute respiratory distress syndrome.Physiological reports · 2022Article
- Effects of zinc status on age-related T cell dysfunction and chronic inflammation.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2021Article
- Effect of Endotoxemia Induced by Intraperitoneal Injection of Lipopolysaccharide on the Mg isotopic Composition of Biofluids and Tissues in Mice.Frontiers in medicine · 2021Article
- Acute peripheral inflammation and post-traumatic sleep differ between sexes after experimental diffuse brain injury.The European journal of neuroscience · 2020Article
- Molecular Dynamics of Lipopolysaccharide-Induced Lung Injury in Rodents.Frontiers in physiology · 2020Review
- Senescence in Pulmonary Fibrosis: Between Aging and Exposure.Frontiers in medicine · 2020Review
- Effect of Systemic Inflammation on Rat Attentional Function and Neuroinflammation: Possible Protective Role for Food Restriction.Frontiers in aging neuroscience · 2019Article
- Article
- Putative Inflammatory Sensitive Mechanisms Underlying Risk or Resilience to Social Stress.Frontiers in behavioral neuroscience · 2018Review
- Age-associated impairment of antitumor immunity in carcinoma-bearing mice and restoration by oral administration of Lentinula edodes mycelia extract.Cancer immunology, immunotherapy : CII · 2016Article
- Diet-induced obesity attenuates cytokine production following an immune challenge.Behavioural brain research · 2014Article
- Combined in silico, in vivo, and in vitro studies shed insights into the acute inflammatory response in middle-aged mice.PloS one · 2013Article
- Dysfunctional nucleus tractus solitarius: its crucial role in promoting neuropathogenetic cascade of Alzheimer's dementia--a novel hypothesis.Neurochemical research · 2012Review
- Sexual dimorphism in cardiac triacylglyceride dynamics in mice on long term caloric restriction.Journal of molecular and cellular cardiology · 2012Article
- Pathogenesis of cognitive dysfunction in patients with obstructive sleep apnea: a hypothesis with emphasis on the nucleus tractus solitarius.Sleep disorders · 2012Article
- Adult hippocampal neurogenesis and c-Fos induction during escalation of voluntary wheel running in C57BL/6J mice.Behavioural brain research · 2010Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Aging can have a profound effect on the neurobehavioral response to immune activation; aged subjects are predisposed to greater deficits in performance and cognitive function in conjunction with an exaggerated neuroinflammatory response. While increased reactivity to an immune insult has been well characterized in aged subjects, the alterations that may exist by middle-age have not been thoroughly investigated. The present study compared the reactions of young (4-month) and middle-age (12-month) male BALB/c mice to an acute or repeated lipopolysaccharide (LPS) challenge(s). The data suggest that in some respects middle-aged mice are more sensitive to endotoxin exposure, as they show enhanced weight loss, splenic cytokine levels, and c-fos expression in the brain following acute LPS administration compared to younger mice. However, acute LPS exposure led to comparable decreases in locomotor activity in young and middle-aged mice. Following repeated LPS administration both age groups showed diminished behavioral and neural reactions to the final LPS challenge, indicating tolerance development. However, the immune system of the middle-aged mice was still mildly responsive to the final LPS exposure, as splenic levels of IL-1beta were significantly elevated. Collectively, the data suggest that middle-age subjects are more sensitive to an immune insult.
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Registered trials
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