ArticleBMC cancer2009
Array-based DNA methylation profiling of primary lymphomas of the central nervous system.
Article in BMC cancer, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed.
- Genome-wide profiling identifies a DNA methylation signature that associates with TET2 mutations in diffuse large B-cell lymphoma.Haematologica · 2013Trial
- Specific Marker Gene Analysis for Primary Central Nervous System Lymphoma Based on Methylation Difference and Development of Detection Primers.Brain and behavior · 2025Article
- Liquid biopsy for improving diagnosis and monitoring of CNS lymphomas: A RANO review.Neuro-oncology · 2024Review
- Semimethylation is a feature of diffuse large B-cell lymphoma, and subgroups with poor prognosis are characterized by global hypomethylation and short telomere length.Clinical epigenetics · 2024Article
- Updates of primary central nervous system lymphoma.Therapeutic advances in hematology · 2024Review
- Review
- Methylated markers accurately distinguish primary central nervous system lymphomas (PCNSL) from other CNS tumors.Clinical epigenetics · 2021Article
- Primary Central Nervous System Lymphoma: Molecular Pathogenesis and Advances in Treatment.Translational oncology · 2019Review
- Role of microRNAs in primary central nervous system lymphomas.Cell proliferation · 2016Review
- Genome-Wide Analysis Uncovers Novel Recurrent Alterations in Primary Central Nervous System Lymphomas.Clinical cancer research : an official journal of the American Association for Cancer Research · 2015Article
- DNA methylation profiling identifies epigenetic dysregulation in pancreatic islets from type 2 diabetic patients.The EMBO journal · 2012Article
- DNA hypomethylation affects cancer-related biological functions and genes relevant in neuroblastoma pathogenesis.PloS one · 2012Article
- Modern concepts in the biology, diagnosis, differential diagnosis and treatment of primary central nervous system lymphoma.Leukemia · 2011Review
- Epigenetic and transcriptional changes which follow Epstein-Barr virus infection of germinal center B cells and their relevance to the pathogenesis of Hodgkin's lymphoma.Journal of virology · 2011Article
- Methylator phenotype of malignant germ cell tumours in children identifies strong candidates for chemotherapy resistance.British journal of cancer · 2011Article
- Primary central nervous system lymphomas: a validation study of array-based comparative genomic hybridization in formalin-fixed paraffin-embedded tumor specimens.Clinical cancer research : an official journal of the American Association for Cancer Research · 2011Article
- Immunohistological profiling by B-cell differentiation status of primary central nervous system lymphoma treated by high-dose methotrexate chemotherapy.Journal of neuro-oncology · 2010Article
- Buckley-James boosting for survival analysis with high-dimensional biomarker data.Statistical applications in genetics and molecular biology · 2010Article
- Radiomic features define risk and are linked to DNA methylation attributes in primary CNS lymphoma.Neuro-oncology advancesArticle
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough primary lymphomas of the central nervous system (PCNSL) and extracerebral diffuse large B-cell lymphoma (DLBCL) cannot be distinguished histologically, it is still a matter of debate whether PCNSL differ from systemic DLBCL with respect to their molecular features and pathogenesis. Analysis of the DNA methylation pattern might provide further data distinguishing these entities at a molecular level.
methodsUsing an array-based technology we have assessed the DNA methylation status of 1,505 individual CpG loci in five PCNSL and compared the results to DNA methylation profiles of 49 DLBCL and ten hematopoietic controls.
resultsWe identified 194 genes differentially methylated between PCNSL and normal controls. Interestingly, Polycomb target genes and genes with promoters showing a high CpG content were significantly enriched in the group of genes hypermethylated in PCNSL. However, PCNSL and systemic DLBCL did not differ in their methylation pattern.
conclusionsBased on the data presented here, PCNSL and DLBCL do not differ in their DNA methylation pattern. Thus, DNA methylation analysis does not support a separation of PCNSL and DLBCL into individual entities. However, PCNSL and DLBCL differ in their DNA methylation pattern from non- malignant controls.
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