ArticleJournal of agricultural and food chemistry2010
Anti-arthritic effects and toxicity of the essential oils of turmeric (Curcuma longa L.).
Article in Journal of agricultural and food chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 116 citations in OpenAlex.
- Trial
- Turmeric (Pharmaceutical biology · 2026Review
- Therapeutic efficacy of Curcuma longa leaf extract in experimental models of arthritis.Inflammopharmacology · 2026Article
- Comparative Effects of Turmeric Secondary Metabolites Across Resorptive Bone Diseases.Metabolites · 2025Article
- An Ethnobotanical Survey and Pharmacological and Toxicity Review of Medicinal Plants Used in the Management of Obesity in the North Central Zone of Nigeria.Journal of obesity · 2025Article
- Sources, morphology, phytochemistry, pharmacology ofFrontiers in pharmacology · 2023Review
- Pharmacological Profile, Bioactivities, and Safety of Turmeric Oil.Molecules (Basel, Switzerland) · 2022Review
- Analysis of Volatile Constituents inPlants (Basel, Switzerland) · 2022Article
- Herbs as an Active Ingredient in Sport: Availability and Information on the Internet.Nutrients · 2022Article
- Bioactive Compound, Antioxidant, and Radical Scavenging Activity of Some Plant Aqueous Extracts for Enhancing Shelf Life of Cold-Stored Rabbit Meat.Antioxidants (Basel, Switzerland) · 2022Article
- Comparative Analysis of Volatile Constituents in Root Tuber and Rhizome ofMolecules (Basel, Switzerland) · 2022Article
- Curcumin-Loaded Human Serum Albumin Nanoparticles Prevent Parkinson's Disease-like Symptoms inNanomaterials (Basel, Switzerland) · 2022Article
- Chemical composition and biological activities of essential oils from six lamiaceae folk medicinal plants.Frontiers in plant science · 2022Article
- Perspective on Improving the Relevance, Rigor, and Reproducibility of Botanical Clinical Trials: Lessons Learned From Turmeric Trials.Frontiers in nutrition · 2021Review
- Essential Oils and Bioactive Components against Arthritis: A Novel Perspective on Their Therapeutic Potential.Plants (Basel, Switzerland) · 2020Review
- Medicinal plants for gingivitis: a review of clinical trials.Iranian journal of basic medical sciences · 2018Review
- Review
- Preparation and Application of Standardized Typical Volatile Components Fraction from Turmeric (Molecules (Basel, Switzerland) · 2018Article
- Simultaneous Quantification of Three Curcuminoids and Three Volatile Components ofMolecules (Basel, Switzerland) · 2018Article
- Employing natural reagents from turmeric and lime for acetic acid determination in vinegar sample.Journal of food and drug analysis · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Turmeric (Curcuma longa L., Zingiberaceae) rhizomes contain two classes of secondary metabolites, curcuminoids and the less well-studied essential oils. Having previously identified potent anti-arthritic effects of the curcuminoids in turmeric extracts in an animal model of rheumatoid arthritis (RA), studies were undertaken to determine whether the turmeric essential oils (TEO) were also joint protective using the same experimental model. Crude or refined TEO extracts dramatically inhibited joint swelling (90-100% inhibition) in female rats with streptococcal cell wall (SCW)-induced arthritis when extracts were administered via intraperitoneal injection to maximize uniform delivery. However, this anti-arthritic effect was accompanied by significant morbidity and mortality. Oral administration of a 20-fold higher dose TEO was nontoxic, but only mildly joint-protective (20% inhibition). These results do not support the isolated use of TEO for arthritis treatment but, instead, identify potential safety concerns in vertebrates exposed to TEO.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.