ReviewThe Laryngoscope2010
Translational systems biology and voice pathophysiology.
Review in The Laryngoscope, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01197339 (Hybrid Model of Vocal Inflammation and Tissue Mobilization), which is not on this map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Hybrid Model of Vocal Inflammation and Tissue Mobilization
Who cites it
12 citing papers in PubMed, 22 citations in OpenAlex.
- Biosimulation of acute phonotrauma: an extended model.The Laryngoscope · 2011Trial
- Vocal Outcomes After Cell-Based Outer Vocal Fold Implant in Porcine Bilateral Vocal Fold Resection.The Laryngoscope · 2026Article
- Establishment of a chemoresistant laryngeal cancer cell model to study chemoresistance and chemosensitization responses via transcriptomic analysis and a tumor-on-a-chip platform.Bioengineering & translational medicine · 2025Article
- An integrated empirical and computational study to decipher help-seeking behaviors and vocal stigma.Communications medicine · 2024Article
- Towards a Physiological Scale of Vocal Fold Agent-Based Models of Surgical Injury and Repair: Sensitivity Analysis, Calibration and Verification.Applied sciences (Basel, Switzerland) · 2019Article
- High-Performance Agent-Based Modeling Applied to Vocal Fold Inflammation and Repair.Frontiers in physiology · 2018Article
- Cellular source and proinflammatory roles of high-mobility group box 1 in surgically injured rat vocal folds.The Laryngoscope · 2017Article
- Computational Modeling of Inflammation and Wound Healing.Advances in wound care · 2013Article
- Methodological approaches to developing and establishing the body of evidence on post-marketing Chinese medicine safety.Chinese journal of integrative medicine · 2013Article
- Translational systems biology of inflammation: potential applications to personalized medicine.Personalized medicine · 2010Article
- Biosimulation of inflammation and healing in surgically injured vocal folds.The Annals of otology, rhinology, and laryngology · 2010Article
- In Situ Visualization for 3D Agent-Based Vocal Fold Inflammation and Repair Simulation.Supercomputing frontiers and innovationsArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
objectives/hypothesisPersonalized medicine has been called upon to tailor healthcare to an individual's needs. Evidence-based medicine (EBM) has advocated using randomized clinical trials with large populations to evaluate treatment effects. However, due to large variations across patients, the results are likely not to apply to an individual patient. We suggest that a complementary, systems biology approach using computational modeling may help tackle biological complexity in order to improve ultimate patient care. The purpose of the article is: 1) to review the pros and cons of EBM, and 2) to discuss the alternative systems biology method and present its utility in clinical voice research. STUDY
designTutorial.
methodsLiterature review and discussion.
resultsWe propose that translational systems biology can address many of the limitations of EBM pertinent to voice and other health care domains, and thus complement current health research models. In particular, recent work using mathematical modeling suggests that systems biology has the ability to quantify the highly complex biologic processes underlying voice pathophysiology. Recent data support the premise that this approach can be applied specifically in the case of phonotrauma and surgically induced vocal fold trauma, and may have particular power to address personalized medicine.
conclusionsWe propose that evidence around vocal health and disease be expanded beyond a population-based method to consider more fully issues of complexity and systems interactions, especially in implementing personalized medicine in voice care and beyond.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.