ArticleIrish journal of medical science2010
Silencing of CT120 by antisense oligonucleotides could inhibit the lung cancer cells growth.
Article in Irish journal of medical science, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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4 citing papers in PubMed, 6 citations in OpenAlex.
- Systematic functional interrogation of genome-wide association studies locus 17p13.3 deciphered role and genetic control of FAM57A in colorectal cancer development.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2024Article
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- CT120A Acts as an Oncogene in Head and Neck Squamous Cell Carcinoma.Journal of Cancer · 2015Article
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Authors and funding
6 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimsThe CT120 gene had been proven to be a novel gene closely related to pulmonary carcinogenesis and cancer progression. Our aim was to explore the mechanism of growth suppression caused by silencing CT120.
methodsCT120 was detected in lung cancer tissues and the cell line A549, and the cell clones for silencing CT120 were obtained. Then the target genes were detected and the downstream proteins from the silencing of CT120 were separated and identified.
resultsThe expression of CT120 was higher in lung cancer tissues and A549 cells. Silencing of CT120 was shown to inhibit cell growth, reduce the expression of cyclin D1 and Cdk4, and increase the expression of p53 and caspase-3. The differential proteins were related to carcinogenesis, invasiveness, and metastasis.
conclusionCT120 may play an important role in tumor progression, and the down-regulation of CT120 expression could be a new drug target candidate in the treatment of lung cancer.
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