ReviewEuropean child & adolescent psychiatry2010
From nature versus nurture, via nature and nurture, to gene x environment interaction in mental disorders.
Review in European child & adolescent psychiatry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 52 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
52 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The prevalence of psychopathology in siblings of children with mental health problems: a 20-year systematic review.Child psychiatry and human development · 2015Pooled it
- Investigating Causality Between Blood Metabolites and Emotional and Behavioral Responses to Traumatic Stress: a Mendelian Randomization Study.Molecular neurobiology · 2020Trial
- Attention, cognitive control and motivation in ADHD: Linking event-related brain potentials and DNA methylation patterns in boys at early school age.Scientific reports · 2017Trial
- Early environmental risks and the developmental dynamics of internalizing and externalizing problems from birth to adolescence.European child & adolescent psychiatry · 2026Article
- Beyond Theory of Mind: mentalization as a relational and developmental framework for autism.Frontiers in psychiatry · 2026Review
- Prevalence of Neurodevelopmental Disorders in Families of Women Taking Psychotropic Medication During Pregnancy.Paediatric and perinatal epidemiology · 2026Article
- Gene-environment interaction in ADHD traits: the role of school environment, personality, callousness-unemotional traits and satisfaction with life.European child & adolescent psychiatry · 2025Article
- Unraveling Attention-Deficit/Hyperactivity Disorder Etiology: Current Challenges and Future Directions in Treatment.NeuroSci · 2025Review
- Prenatal gene-environment interactions mediate the impact of advanced maternal age on mouse offspring behavior.Scientific reports · 2024Article
- Right frontal cingulate cortex mediates the effect of prenatal complications on youth internalizing behaviors.Molecular psychiatry · 2024Article
- Genotype-Environment Interaction in ADHD: Genetic Predisposition Determines the Extent to Which Environmental Influences Explain Variability in the Symptom Dimensions Hyperactivity and Inattention.Behavior genetics · 2024Article
- Relative brain age is associated with socioeconomic status and anxiety/depression problems in youth.Developmental psychology · 2024Article
- MAOA uVNTR Polymorphism Influence on Older Adults Diagnosed with Diabetes Mellitus/Systemic Arterial Hypertension.Journal of aging research · 2023Article
- Article
- Prenatal and perinatal factors associated with ADHD risk in schoolchildren: EPINED epidemiological study.European child & adolescent psychiatry · 2021Article
- Interaction between lead and noradrenergic genotypes affects neurocognitive functions in attention-deficit/hyperactivity disorder: a case control study.BMC psychiatry · 2020Article
- Impact of autism-associated genetic variants in interaction with environmental factors on ADHD comorbidities: an exploratory pilot study.Journal of neural transmission (Vienna, Austria : 1996) · 2019Article
- Children's DAT1 Polymorphism Moderates the Relationship Between Parents' Psychological Profiles, Children's DAT Methylation, and Their Emotional/Behavioral Functioning in a Normative Sample.International journal of environmental research and public health · 2019Article
- LPHN3 gene variations and susceptibility to ADHD in Chinese Han population: a two-stage case-control association study and gene-environment interactions.European child & adolescent psychiatry · 2019Article
- Maternal stress in Shank3ex4-9 mice increases pup-directed care and alters brain white matter in male offspring.PloS one · 2019Article
Corrections and comments
- Erratum issuedBanaschweski, Tobias [corrected to Banaschewski, Tobias]
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is now generally accepted that complex mental disorders are the results of interplay between genetic and environmental factors. This holds out the prospect that by studying G x E interplay we can explain individual variation in vulnerability and resilience to environmental hazards in the development of mental disorders. Furthermore studying G x E findings may give insights in neurobiological mechanisms of psychiatric disorder and so improve individualized treatment and potentially prevention. In this paper, we provide an overview of the state of field with regard to G x E in mental disorders. Strategies for G x E research are introduced. G x E findings from selected mental disorders with onset in childhood or adolescence are reviewed [such as depressive disorders, attention-deficit/hyperactivity disorder (ADHD), obesity, schizophrenia and substance use disorders]. Early seminal studies provided evidence for G x E in the pathogenesis of depression implicating 5-HTTLPR, and conduct problems implicating MAOA. Since then G x E effects have been seen across a wide range of mental disorders (e.g., ADHD, anxiety, schizophrenia, substance abuse disorder) implicating a wide range of measured genes and measured environments (e.g., pre-, peri- and postnatal influences of both a physical and a social nature). To date few of these G x E effects have been sufficiently replicated. Indeed meta-analyses have raised doubts about the robustness of even the most well studied findings. In future we need larger, sufficiently powered studies that include a detailed and sophisticated characterization of both phenotype and the environmental risk.
Indexed as
Identifiers
20024596What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.