Evidence map›Paper›PMID 20024330›Full record

ArticleChemical communications (Cambridge, England)2010

Spontaneous and reversible self-assembly of a polypeptide fragment of insulin-like growth factor binding protein-2 into fluorescent nanotubular structures.

Monalisa Swain, R Thirupathi, B Krishnarjuna, Erin M Eaton, Megan M Kibbey, Steven A Rosenzweig, Hanudatta S Atreya

Open access · greenAbstract read
In one paragraph

Article in Chemical communications (Cambridge, England), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Monalisa SwainNMR Research Centre, Indian Institute of Science, Bangalore-560012, India.
R Thirupathi
B Krishnarjuna
Erin M Eaton
Megan M Kibbey
Steven A Rosenzweig
Hanudatta S Atreya
Indian Institute of Science Bangalore · INMedical University of South Carolina · US

Funding

Translational Science Laboratory Shared ResourceP30CA138313 · NCI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI RAYMOND N. DUBOIS · 2009 to 2026
$42.7M
Receptor Crosstalk in HNSCC Metastatic ProgressionR01CA134845 · NCI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI ROSENZWEIG, STEVEN ALAN · 2009 to 2016
$1.6M
INHIBITION OF IGF MEDIATED TUMORIGENESISR01CA078887 · NCI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI ROSENZWEIG, STEVEN A. · 2000 to 2004
$1.4M
NCI NIH HHS P30 CA138313NCI NIH HHS R01 CA078887NCI NIH HHS R01 CA134845NCI NIH HHS R01CA134845NCI NIH HHS R01CA78887
6 · The paper itself

Abstract

In this communication, we report the spontaneous and reversible in vitro self-assembly of a polypeptide fragment derived from the C-terminal domain of Insulin-like Growth Factor Binding Protein (IGFBP-2) into soluble nanotubular structures several micrometres long via a mechanism involving inter-molecular disulfide bonds and exhibiting enhanced fluorescence.

Indexed as

Amino Acid SubstitutionFluorescent DyesInsulin-Like Growth Factor Binding Protein 2Magnetic Resonance SpectroscopyMicroscopy, FluorescenceMutagenesis, Site-DirectedNanotubesProtein FoldingFluorescent DyesInsulin-Like Growth Factor Binding Protein 2

Identifiers

PMID20024330
PMCPMC4144806
OpenAlexW2093619082

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.