ArticleMolecular bioSystems2010
Rapid identification of orexin receptor binding ligands using cell-based screening accelerated with magnetic beads.
Article in Molecular bioSystems, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed.
- Discovery of Inhibitors for Proliferating Cell Nuclear Antigen Using a Computational-Based Linked-Multiple-Fragment Screen.ACS omega · 2019Article
- Discovery of Peptidomimetic Ligands of EED as Allosteric Inhibitors of PRC2.ACS combinatorial science · 2017Article
- Tumor-targeting peptides from combinatorial libraries.Advanced drug delivery reviews · 2017Review
- Development of a large peptoid-DOTA combinatorial library.Biopolymers · 2016Article
- Design of a Microfluidic Chip for Magnetic-Activated Sorting of One-Bead-One-Compound Libraries.ACS combinatorial science · 2016Article
- Identification of novel peptoid agonists of fibroblast growth factor receptor using microarray-based screening.MedChemComm · 2016Article
- The identification of high-affinity G protein-coupled receptor ligands from large combinatorial libraries using multicolor quantum dot-labeled cell-based screening.Future medicinal chemistry · 2014Review
- Synthetic receptors with antibody-like binding affinities.Current opinion in chemical biology · 2010Review
- Solid-phase synthesis of N-substituted glycine oligomers (alpha-peptoids) and derivatives.Molecules (Basel, Switzerland) · 2010Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
We report here a simple and rapid method by which to screen one bead one compound libraries for highly specific ligands to cell surface proteins such as G protein-coupled receptors. This protocol, which harvests "hits" in a cell-based binding screen magnetically, eliminates the most tedious aspects of previously published bead screening techniques and allows millions of different compounds to be screened rapidly and cheaply. The method is demonstrated using the orexin receptor 1, which resulted in the isolation of moderate potency antagonists.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.