ArticleLab on a chip2010
A new method for studying gradient-induced neutrophil desensitization based on an open microfluidic chamber.
Article in Lab on a chip, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 67 citations in OpenAlex.
- Passive redirection filters minimize red blood cell contamination during neutrophil chemotaxis assays using whole blood.Lab on a chip · 2023Article
- Generation of Dynamic Concentration Profile Using A Microfluidic Device Integrating Pneumatic Microvalves.Biosensors · 2022Article
- Engineering physical microenvironments to study innate immune cell biophysics.APL bioengineering · 2022Review
- On-Chip Micro Mixer Driven by Elastic Wall with Virtual Actuator.Micromachines · 2021Article
- Microfluidic Systems to Study Neutrophil Forward and Reverse Migration.Frontiers in immunology · 2021Review
- Push/Pull Inequality Based High-Speed On-Chip Mixer Enhanced by Wettability.Micromachines · 2020Article
- Microfluidic devices for neutrophil chemotaxis studies.Journal of translational medicine · 2020Review
- Chemotactic Responses of Jurkat Cells in Microfluidic Flow-Free Gradient Chambers.Micromachines · 2020Article
- "Chip-on-a-Transwell" Devices for User-Friendly Control of the Microenvironment of Cultured Cells.ACS applied bio materials · 2019Article
- Recent advances in microfluidics for drug screening.Biomicrofluidics · 2019Review
- A Gal-MµS Device to Evaluate Cell Migratory Response to Combined Galvano-Chemotactic Fields.Biosensors · 2017Article
- A 3D-printed microbial cell culture platform withBiomicrofluidics · 2017Article
- Microfluidic Concentric Gradient Generator Design for High-Throughput Cell-Based Studies.Frontiers in bioengineering and biotechnology · 2017Article
- Big insights from small volumes: deciphering complex leukocyte behaviors using microfluidics.Journal of leukocyte biology · 2016Review
- Simultaneous or Sequential Orthogonal Gradient Formation in a 3D Cell Culture Microfluidic Platform.Small (Weinheim an der Bergstrasse, Germany) · 2016Article
- Simple microfluidic device for studying chemotaxis in response to dual gradients.Biomedical microdevices · 2015Article
- Microdevice integrating innate and adaptive immune responses associated with antigen presentation by dendritic cells.RSC advances · 2013Article
- Suspended microfluidics.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Microfluidic investigation of BDNF-enhanced neural stem cell chemotaxis in CXCL12 gradients.Small (Weinheim an der Bergstrasse, Germany) · 2013Article
- On-chip open microfluidic devices for chemotaxis studies.Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
Abstract
During inflammation neutrophils rapidly migrate to the site of tissue damage or infection by following complex gradients of bacterial peptides and host-derived chemokines. The efficiency and speed of neutrophil migration is critically dependent upon the ability of neutrophils to sense new gradients and utilize only those that provide the most direct path to the damaged or infected site. Receptor desensitization plays an important role in migration efficiency and is most commonly studied using bath application of chemotactic factor solutions instead of presenting cells with gradients analogous to those they would experience in vivo. Here we describe a new method for examining gradient-induced neutrophil desensitization using a previously-developed open-chamber microfluidic gradient generator.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.