ReviewIntegrative biology : quantitative biosciences from nano to macro2009
Microparticle encoding technologies for high-throughput multiplexed suspension assays.
Review in Integrative biology : quantitative biosciences from nano to macro, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed.
- Expanding High-Fidelity Multiplexing in Ultrasensitive Single-Molecule Protein Detection via Proximity Barcoding.Angewandte Chemie (International ed. in English) · 2026Article
- Encoding microcarriers for biomedicine.Smart medicine · 2023Review
- Multiplex Assay for Rapid Detection and Analysis of Nucleic Acid Using Barcode Receptor Encoded Particle (BREP).Biomedicines · 2022Article
- Paramagnetic encoding of molecules.Nature communications · 2022Article
- Fluorescence calibration standards made from broadband emitters encapsulated in polymer beads for fluorescence microscopy and flow cytometry.Analytical and bioanalytical chemistry · 2020Article
- MRBLES 2.0: High-throughput generation of chemically functionalized spectrally and magnetically encoded hydrogel beads using a simple single-layer microfluidic device.Microsystems & nanoengineering · 2020Article
- Ultrasimple Single-Cell Detection of Multiple Cytokines by a Nanowell Chip Integrated with Encoded Microarrays.ACS sensors · 2019Article
- AIEgens Barcodes Combined with AIEgens Nanobeads for High-sensitivity Multiplexed Detection.Theranostics · 2019Article
- Optimizing Multiplexed Detections of Diabetes Antibodies via Quantitative Microfluidic Droplet Array.Small (Weinheim an der Bergstrasse, Germany) · 2017Article
- Cell Microarray Technologies for High-Throughput Cell-Based Biosensors.Sensors (Basel, Switzerland) · 2017Review
- Bioengineering Microgels and Hydrogel Microparticles for Sensing Biomolecular Targets.Gels (Basel, Switzerland) · 2017Review
- Programmable Microfluidic Synthesis of Over One Thousand Uniquely Identifiable Spectral Codes.Advanced optical materials · 2017Article
- In-flow real-time detection of spectrally encoded microgels for miRNA absolute quantification.Biomicrofluidics · 2016Article
- Hydrogel microparticles for biosensing.European polymer journal · 2015Article
- Suspension arrays based on nanoparticle-encoded microspheres for high-throughput multiplexed detection.Chemical Society reviews · 2015Review
- Fiber composite slices for multiplexed immunoassays.Biomicrofluidics · 2015Article
- Direct identification of on-bead peptides using surface-enhanced Raman spectroscopic barcoding system for high-throughput bioanalysis.Scientific reports · 2015Article
- Multiplexed DNA detection based on positional encoding/decoding with self-assembled DNA nanostructures.Chemical science · 2015Article
- Absolute and Relative Quantification of Multiplex DNA Assays Based on an Elemental Labeling Strategy.Angewandte Chemie (Weinheim an der Bergstrasse, Germany) · 2013Article
- Absolute and relative quantification of multiplex DNA assays based on an elemental labeling strategy.Angewandte Chemie (International ed. in English) · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The requirement for analysis of large numbers of biomolecules for drug discovery and clinical diagnostics has driven the development of low-cost, flexible and high-throughput methods for simultaneous detection of multiple molecular targets in a single sample (multiplexed analysis). The technique that seems most likely to satisfy all of these requirements is the multiplexed suspension (bead-based) assay, which offers a number of advantages over alternative approaches such as ELISAs and microarrays. In a bead based assay, different probe molecules are attached to different beads (of a few tens of microns in size), which are then reacted in suspension with the target sample. After reaction, the beads must be identifiable in order to determine the attached probe molecule, and thus each bead must be labelled (encoded) with a unique identifier. A large number of techniques have been proposed for encoding beads. This critical review analyses each technology on the basis of its ability to fulfil the practical requirements of assays, whilst being compatible with low-cost, high-throughput manufacturing processes and high-throughput detection methods. As a result, we identify the most likely candidates to be used for future integrated device development for practical applications.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.