ArticlePlant signaling & behavior2010
Sterol biosynthesis in oomycete pathogens.
Article in Plant signaling & behavior, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 71 citations in OpenAlex.
- Metabolomic Analysis of Phytophthora parasitica Growth in the Presence of β-sitosterol Indicates Adaptive Mechanisms Modulated by Sterols.Journal of basic microbiology · 2026Article
- Engineered elicitin protein enhances Phytophthora resistance in plants by dual immune induction and pathogen inhibition.Stress biology · 2025Article
- In vitro effects of potato glycoalkaloids on plant-pathogens, beneficial microbes, and Arabidopsis thaliana.Scientific reports · 2025Article
- Novel endornaviruses infectingThe Journal of general virology · 2025Article
- Anti-Pythium insidiosum activity of three novel triazole compounds: synthesis, pharmacokinetic and toxicological parameters.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2025Article
- Loss of Sterol Biosynthesis in Economically Important Plant Pests and Pathogens: A Review of a Potential Target for Pest Control.Biomolecules · 2024Review
- Two structurally different oomycete lipophilic microbe-associated molecular patterns induce distinctive plant immune responses.Plant physiology · 2024Article
- Treating Pythiosis with Antibacterial Drugs Targeting Protein Synthesis: An Overview.Journal of fungi (Basel, Switzerland) · 2024Review
- Harnessing Plant's Arsenal: Essential Oils as Promising Tools for Sustainable Management of Potato Late Blight Disease Caused byMolecules (Basel, Switzerland) · 2023Review
- Sterol-Sensing Domain (SSD)-Containing Proteins in Sterol AuxotrophicMicrobiology spectrum · 2023Article
- Elucidation of sterol biosynthesis pathway and its co-regulation with fatty acid biosynthesis in the oleaginous marine protistFrontiers in bioengineering and biotechnology · 2023Article
- An in-planta comparative study of Plasmopara viticola proteome reveals different infection strategies towards susceptible and Rpv3-mediated resistance hosts.Scientific reports · 2022Article
- The Disease Progression and Molecular Defense Response inPlants (Basel, Switzerland) · 2022Article
- Secondary Metabolites from the Endoparasitic Nematophagous FungusMicroorganisms · 2022Article
- Secretome Profiling by Proteogenomic Analysis Shows Species-Specific, Temperature-Dependent, and Putative Virulence Proteins ofJournal of fungi (Basel, Switzerland) · 2022Article
- Article
- Ecological Dynamics and Microbial Treatments against Oomycete Plant Pathogens.Plants (Basel, Switzerland) · 2021Review
- Predicting Lifestyle from Positive Selection Data and Genome Properties in Oomycetes.Pathogens (Basel, Switzerland) · 2021Article
- A Cytochrome BFrontiers in plant science · 2021Article
- Identification of Candidate Ergosterol-Responsive Proteins Associated with the Plasma Membrane ofInternational journal of molecular sciences · 2019Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oomycetes are a diverse group of filamentous eukaryotic microbes comprising devastating animal and plant pathogens. They share many characteristics with fungi, including polarized hyphal extension and production of spores, but phylogenetics studies have clearly placed oomycetes outside the fungal kingdom, in the kingdom Stramenopila which also includes marine organisms such as diatoms and brown algae. Oomycetes display various specific biochemical features, including sterol metabolism. Sterols are essential isoprenoid compounds involved in membrane function and hormone signaling. Oomycetes belonging to Peronosporales, such as Phytophthora sp., are unable to synthesize their own sterols and must acquire them from their plant or animal hosts. In contrast, a combination of biochemical and molecular approaches allowed us to decipher a nearly complete sterol biosynthetic pathway leading to fucosterol in the legume pathogen Aphanomyces euteiches, an oomycete belonging to Saprolegniales. Importantly, sterol demethylase, a key enzyme from this pathway, is susceptible to chemicals widely used in agriculture and medicine as antifungal drugs, suggesting that similar products could be used against plant and animal diseases caused by Saprolegniales.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.