ArticleIn vivo (Athens, Greece)
Further studies on the frequency and length of the glandulo-metaplastic esophageal mucosa in baboons.
Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 7 citations in OpenAlex.
- The length of the Barrett's mucosa in baboons, revisited.Anticancer research · 2012Article
- Mucous gland metaplasia in the esophagus and gastric mucosa in baboons.Anticancer research · 2011Article
- Further studies on Barretts mucosa in baboons: metaplastic glandular cells produce sialomucin.Anticancer research · 2010Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
backgroundIn previous studies, the length of the glandulo-metaplastic esophageal mucosa (GMEM) at the gastroesophageal junction was assessed in a selected group of baboons. In this study, the length of the GMEM was measured in the entire esophagus in a cohort of unselected adult baboons. MATERIALS AND
methodsIn 15 female baboons, the entire esophagus was removed en bloc at autopsy, from the tongue to the angle of His. No part of the stomach was included. The length of GMEM was measured using a calibrated ocular microscale.
resultsGMEM was found in 11 out of the 15 esophagi. The total length of GMEM recorded in the 11 cases was 115 mm (mean 10.5 mm, range 1-45 mm). The mean age for animals with GMEM was 15.5 years (range 7-32 years) and for animals without GMEM was 14.0 years (range 7-20 years); the difference was non-significant (p<0.6). No significant association was found between the length of the GMEM and the age of the animals (p<0.6).
conclusionThis study substantiates the notion that GMEM in baboons is a postnatal physiological adaptative process of the esophageal mucosa to daily regurgitation with rumination of gastric juices of low pH. The GMEM apparently progresses upwards, along the esophageal mucosa. The baboon might be an excellent animal model to study the series of histological events that take place in the distal esophagus under the influence of protracted gastroesophageal reflux.
Indexed as
Identifiers
20023239PMC3479656W2187496793What OpenQuestion holds
Registered trials
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