ArticleDevelopment (Cambridge, England)2010
Interaction between Drosophila bZIP proteins Atf3 and Jun prevents replacement of epithelial cells during metamorphosis.
Article in Development (Cambridge, England), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 29 citations in OpenAlex.
- A transcription factor by any other name - function beyond DNA binding and transactivation.EMBO reports · 2026Review
- The Hippo signalling pathway regulates the timing of epithelial cell replacement during Drosophila abdominal morphogenesis.Journal of cell science · 2026Article
- Juvenile hormone receptor relies on conserved domain interfaces for dimerization-dependent activity.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Emerging roles for integrated stress response signaling in homeostasis.The FEBS journal · 2025Review
- Closing the gap: Nonviral TFAMoplex transfection boosted by bZIP domains compared to AAV-mediated transduction.Molecular therapy. Nucleic acids · 2025Article
- Phenotypic and transcriptomic impact of expressing mammalian TET2 in theEpigenetics · 2023Article
- Sample Preparation and Imaging of the Pupal Drosophila Abdominal Epidermis.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Article
- Effects of flanking sequences and cellular context on subcellular behavior and pathology of mutant HTT.Human molecular genetics · 2020Article
- DamID profiling of dynamic Polycomb-binding sites in Drosophila imaginal disc development and tumorigenesis.Epigenetics & chromatin · 2018Article
- Atf3 links loss of epithelial polarity to defects in cell differentiation and cytoarchitecture.PLoS genetics · 2018Article
- The Drosophila Duox maturation factor is a key component of a positive feedback loop that sustains regeneration signaling.PLoS genetics · 2017Article
- An accelerated miRNA-based screen implicates Atf-3 in Drosophila odorant receptor expression.Scientific reports · 2016Article
- Interplay among Drosophila transcription factors Ets21c, Fos and Ftz-F1 drives JNK-mediated tumor malignancy.Disease models & mechanisms · 2015Article
- The Drosophila MAPK p38c regulates oxidative stress and lipid homeostasis in the intestine.PLoS genetics · 2014Article
- Activating transcription factor 3 regulates immune and metabolic homeostasis.Molecular and cellular biology · 2012Article
- Lamellipodia-based migrations of larval epithelial cells are required for normal closure of the adult epidermis of Drosophila.Developmental biology · 2012Article
- Article
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Authors and funding
4 authors at 4 institutions in 3 countries.
Funding
Abstract
Epithelial sheet spreading and fusion underlie important developmental processes. Well-characterized examples of such epithelial morphogenetic events have been provided by studies in Drosophila, and include embryonic dorsal closure, formation of the adult thorax and wound healing. All of these processes require the basic region-leucine zipper (bZIP) transcription factors Jun and Fos. Much less is known about morphogenesis of the fly abdomen, which involves replacement of larval epidermal cells (LECs) with adult histoblasts that divide, migrate and finally fuse to form the adult epidermis during metamorphosis. Here, we implicate Drosophila Activating transcription factor 3 (Atf3), the single ortholog of human ATF3 and JDP2 bZIP proteins, in abdominal morphogenesis. During the process of the epithelial cell replacement, transcription of the atf3 gene declines. When this downregulation is experimentally prevented, the affected LECs accumulate cell-adhesion proteins and their extrusion and replacement with histoblasts are blocked. The abnormally adhering LECs consequently obstruct the closure of the adult abdominal epithelium. This closure defect can be either mimicked and further enhanced by knockdown of the small GTPase Rho1 or, conversely, alleviated by stimulating ecdysone steroid hormone signaling. Both Rho and ecdysone pathways have been previously identified as effectors of the LEC replacement. To elicit the gain-of-function effect, Atf3 specifically requires its binding partner Jun. Our data thus identify Atf3 as a new functional partner of Drosophila Jun during development.
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