ArticleDevelopment (Cambridge, England)2010
Evidence for a role of vertebrate Disp1 in long-range Shh signaling.
Article in Development (Cambridge, England), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed.
- Unravelling the Mysteries of the Sonic Hedgehog Pathway in Cancer Stem Cells: Activity, Crosstalk and Regulation.Current issues in molecular biology · 2024Review
- Article
- Sonic hedgehog is basolaterally sorted from the TGN and transcytosed to the apical domain involving Dispatched-1 at Rab11-ARE.Frontiers in cell and developmental biology · 2022Article
- Structural insights into proteolytic activation of the human Dispatched1 transporter for Hedgehog morphogen release.Nature communications · 2021Article
- Hedgehog signaling and the primary cilium: implications for spatial and temporal constraints on signaling.Development (Cambridge, England) · 2021Review
- Architecture of Dispatched, a Transmembrane Protein Responsible for Hedgehog Release.Frontiers in molecular biosciences · 2021Article
- Structure of human Dispatched-1 provides insights into Hedgehog ligand biogenesis.Life science alliance · 2020Article
- Polarized sorting of Patched enables cytoneme-mediated Hedgehog reception in the Drosophila wing disc.The EMBO journal · 2020Article
- Cryo-EM structure of the Hedgehog release protein Dispatched.Science advances · 2020Article
- Structural basis of sterol recognition by human hedgehog receptor PTCH1.Science advances · 2019Article
- Loss of the Heparan Sulfate Proteoglycan Glypican5 Facilitates Long-Range Sonic Hedgehog Signaling.Stem cells (Dayton, Ohio) · 2019Article
- Dispatching Sonic Hedgehog: Molecular Mechanisms Controlling Deployment.Trends in cell biology · 2019Review
- Expression of dispatched RND transporter family member 1 is decreased in the diaphragmatic and pulmonary mesenchyme of nitrofen-induced congenital diaphragmatic hernia.Pediatric surgery international · 2019Article
- Psychopharmacological Treatment of Obsessive-Compulsive Disorder (OCD).Current neuropharmacology · 2019Review
- From top to bottom: Cell polarity in Hedgehog and Wnt trafficking.BMC biology · 2018Review
- Article
- A fixation method to preserve cultured cell cytonemes facilitates mechanistic interrogation of morphogen transport.Development (Cambridge, England) · 2017Article
- Computational Model of Secondary Palate Fusion and Disruption.Chemical research in toxicology · 2017Article
- Perspectives on Intra- and Intercellular Trafficking of Hedgehog for Tissue Patterning.Journal of developmental biology · 2016Review
- Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Dispatched 1 (Disp1) encodes a twelve transmembrane domain protein that is required for long-range sonic hedgehog (Shh) signaling. Inhibition of Disp1 function, both by RNAi or dominant-negative constructs, prevents secretion and results in the accumulation of Shh in source cells. Measuring the Shh response in neuralized embryoid bodies (EBs) derived from embryonic stem (ES) cells, with or without Disp1 function, demonstrates an additional role for Disp1 in cells transporting Shh. Co-cultures with Shh-expressing cells revealed a significant reduction in the range of the contact-dependent Shh response in Disp1(-/-) neuralized EBs. These observations support a dual role for Disp1, not only in the secretion of Shh from the source cells, but also in the subsequent transport of Shh through tissue.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.