ArticleApplied and environmental microbiology2010
Functional role of Bradyrhizobium japonicum trehalose biosynthesis and metabolism genes during physiological stress and nodulation.
Article in Applied and environmental microbiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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37 citing papers in PubMed, 88 citations in OpenAlex.
- Insights into trehalose synthase function in the rhizobiumSustainable microbiology · 2026Article
- Fit for purpose: evaluation and evolution of agricultural bioinoculants across production landscapes.ISME communications · 2026Review
- Genomic insights into novel predatory myxobacteria isolated from human feces.Microbiology spectrum · 2025Article
- Synergistic co-metabolism enhancing the crude oil degradation byMicrobiology spectrum · 2025Article
- Genetic Characterization and Symbiotic Performance of Soybean Rhizobia Under Cold and Water-Deficient Conditions in Poland.Plants (Basel, Switzerland) · 2025Article
- Comparative genomic analysis ofMicrobiology spectrum · 2024Article
- Exploring potential soybean bradyrhizobia from high trehalose-accumulating soybean genotypes for improved symbiotic effectiveness in soybean.International microbiology : the official journal of the Spanish Society for Microbiology · 2023Article
- The Type IV Secretion System (T4SS) Mediates Symbiosis betweenApplied and environmental microbiology · 2023Article
- Genome of Paspalum vaginatum and the role of trehalose mediated autophagy in increasing maize biomass.Nature communications · 2022Article
- Novel metabolic interactions and environmental conditions mediate the boreal peatmoss-cyanobacteria mutualism.The ISME journal · 2022Article
- Effects of rehydration on physiological and transcriptional responses of a water-stressed rhizobium.Journal of microbiology (Seoul, Korea) · 2022Article
- Trehalose and α-glucan mediate distinct abiotic stress responses in Pseudomonas aeruginosa.PLoS genetics · 2021Article
- Article
- Revealing the salinity adaptation mechanism in halotolerant bacterium Egicoccus halophilus EGI 80432Applied microbiology and biotechnology · 2021Article
- Study of thermotolerant mechanism ofMycoscience · 2021Article
- Trehalose and bacterial virulence.Virulence · 2020Review
- Salt Stress Response of Sulfolobus acidocaldarius Involves Complex Trehalose Metabolism Utilizing a Novel Trehalose-6-Phosphate Synthase (TPS)/Trehalose-6-Phosphate Phosphatase (TPP) Pathway.Applied and environmental microbiology · 2020Article
- Deciphering the Role of Trehalose in Tripartite Symbiosis Among Rhizobia, Arbuscular Mycorrhizal Fungi, and Legumes for Enhancing Abiotic Stress Tolerance in Crop Plants.Frontiers in microbiology · 2020Review
- The Production of ACC Deaminase and Trehalose by the Plant Growth Promoting BacteriumFrontiers in microbiology · 2019Article
- A network of regulators promotes dehydration tolerance in Escherichia coli.Environmental microbiology · 2018Article
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Authors and funding
3 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Trehalose, a disaccharide accumulated by many microorganisms, acts as a protectant during periods of physiological stress, such as salinity and desiccation. Previous studies reported that the trehalose biosynthetic genes (otsA, treS, and treY) in Bradyrhizobium japonicum were induced by salinity and desiccation stresses. Functional mutational analyses indicated that disruption of otsA decreased trehalose accumulation in cells and that an otsA treY double mutant accumulated an extremely low level of trehalose. In contrast, trehalose accumulated to a greater extent in a treS mutant, and maltose levels decreased relative to that seen with the wild-type strain. Mutant strains lacking the OtsA pathway, including the single, double, and triple DeltaotsA, DeltaotsA DeltatreS and DeltaotsA DeltatreY, and DeltaotsA DeltatreS DeltatreY mutants, were inhibited for growth on 60 mM NaCl. While mutants lacking functional OtsAB and TreYZ pathways failed to grow on complex medium containing 60 mM NaCl, there was no difference in the viability of the double mutant strain when cells were grown under conditions of desiccation stress. In contrast, mutants lacking a functional TreS pathway were less tolerant of desiccation stress than the wild-type strain. Soybean plants inoculated with mutants lacking the OtsAB and TreYZ pathways produced fewer mature nodules and a greater number of immature nodules relative to those produced by the wild-type strain. Taken together, results of these studies indicate that stress-induced trehalose biosynthesis in B. japonicum is due mainly to the OtsAB pathway and that the TreS pathway is likely involved in the degradation of trehalose to maltose. Trehalose accumulation in B. japonicum enhances survival under conditions of salinity stress and plays a role in the development of symbiotic nitrogen-fixing root nodules on soybean plants.
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