ArticleEukaryotic cell2010
Hgc1 mediates dynamic Candida albicans-endothelium adhesion events during circulation.
Article in Eukaryotic cell, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 43 citations in OpenAlex.
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- Assessment of NK cytotoxicity and interactions with porcine endothelial cells by live-cell imaging in 2D static and 3D microfluidic systems.Scientific reports · 2024Article
- Organ-on-chip models for infectious disease research.Nature microbiology · 2024Review
- In vitro infection models to study fungal-host interactions.FEMS microbiology reviews · 2021Review
- The impact of the Fungus-Host-Microbiota interplay upon Candida albicans infections: current knowledge and new perspectives.FEMS microbiology reviews · 2021Review
- Article
- A new perspective in sepsis treatment: could RGD-dependent integrins be novel targets?Drug discovery today · 2020Review
- Redundant Trojan horse and endothelial-circulatory mechanisms for host-mediated spread of Candida albicans yeast.PLoS pathogens · 2020Article
- Cooperative Role of MAPK Pathways in the Interaction ofMicroorganisms · 2019Article
- 3D artificial round section micro-vessels to investigate endothelial cells under physiological flow conditions.Scientific reports · 2018Article
- TheFrontiers in cellular and infection microbiology · 2018Article
- A Flow-assay for Farnesol Removal from AdherentBio-protocol · 2017Article
- Zinc Limitation Induces a Hyper-Adherent Goliath Phenotype inFrontiers in microbiology · 2017Article
- Genomic and Phenotypic Variation in Morphogenetic Networks of TwoFrontiers in immunology · 2017Article
- The Missing Link between Candida albicans Hyphal Morphogenesis and Host Cell Damage.PLoS pathogens · 2016Review
- Innate immune cell response upon Candida albicans infection.Virulence · 2016Review
- Hgc1-Cdc28-how much does a single protein kinase do in the regulation of hyphal development in Candida albicans?Journal of microbiology (Seoul, Korea) · 2016Review
- Distinct cell cycle regulation during saprophytic and pathogenic growth in fungal pathogens.Current genetics · 2016Article
- Role of force-sensitive amyloid-like interactions in fungal catch bonding and biofilms.Eukaryotic cell · 2014Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Common iatrogenic procedures can result in translocation of the human pathogenic fungus Candida albicans from mucosal surfaces to the bloodstream. Subsequent disseminated candidiasis and infection of deep-seated organs may occur if the fungus is not eliminated by blood cells. In these cases, fungal cells adhere to the endothelial cells of blood vessels, penetrate through endothelial layers, and invade deeper tissue. In this scenario, endothelial adhesion events must occur during circulation under conditions of physiological blood pressure. To investigate the fungal and host factors which contribute to this essential step of disseminated candidiasis, we have developed an in vitro circulatory C. albicans-endothelium interaction model. We demonstrate that both C. albicans yeast and hyphae can adhere under flow at a pressure similar to capillary blood pressure. Serum factors significantly enhanced the adhesion potential of viable but not killed C. albicans cells to endothelial cells. During circulation, C. albicans cells produced hyphae and the adhesion potential first increased, then decreased with time. We provide evidence that a specific temporal event in the yeast-to-hyphal transition, regulated by the G(1) cyclin Hgc1, is critical for C. albicans-endothelium adhesion during circulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.