ArticleEukaryotic cell2010
Candida albicans PEP12 is required for biofilm integrity and in vivo virulence.
Article in Eukaryotic cell, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 33 citations in OpenAlex.
- Endocytosis Mediated byMicroorganisms · 2026Article
- The Early Endocytosis GeneJournal of fungi (Basel, Switzerland) · 2023Article
- A C. albicans TRAPP Complex-Associated Gene Contributes to Cell Wall Integrity, Hyphal and Biofilm Formation, and Tissue Invasion.Microbiology spectrum · 2023Article
- Lactobacillus rhamnosus colonisation antagonizes Candida albicans by forcing metabolic adaptations that compromise pathogenicity.Nature communications · 2022Article
- Candida albicansmSphere · 2021Article
- The Lack of SNARE Protein Homolog Syn8 Influences Biofilm Formation ofFrontiers in cell and developmental biology · 2021Article
- The Role of Secretory Pathways inJournal of fungi (Basel, Switzerland) · 2020Review
- Candida albicans-Induced Epithelial Damage Mediates Translocation through Intestinal Barriers.mBio · 2018Article
- A pre-therapeutic coating for medical devices that prevents the attachment of Candida albicans.Annals of clinical microbiology and antimicrobials · 2017Article
- pH-Dependant Antifungal Activity of Valproic Acid against the Human Fungal PathogenFrontiers in microbiology · 2017Article
- Identification of small molecules that disrupt vacuolar function in the pathogen Candida albicans.PloS one · 2017Article
- Pleiotropic effects of the vacuolar ABC transporter MLT1 of Candida albicans on cell function and virulence.The Biochemical journal · 2016Article
- Candida Biofilms: Development, Architecture, and Resistance.Microbiology spectrum · 2015Review
- New "haploid biofilm model" unravels IRA2 as a novel regulator of Candida albicans biofilm formation.Scientific reports · 2015Article
- Trafficking through the late endosome significantly impacts Candida albicans tolerance of the azole antifungals.Antimicrobial agents and chemotherapy · 2015Article
- Candida albicans Biofilms and Human Disease.Annual review of microbiology · 2015Review
- Distinct roles of Candida albicans-specific genes in host-pathogen interactions.Eukaryotic cell · 2014Article
- Secretion and filamentation are mediated by the Candida albicans t-SNAREs Sso2p and Sec9p.FEMS yeast research · 2014Article
- Advances in targeting the vacuolar proton-translocating ATPase (V-ATPase) for anti-fungal therapy.Frontiers in pharmacology · 2014Review
- Candida albicans VPS4 contributes differentially to epithelial and mucosal pathogenesis.Virulence · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
To investigate the role of the prevacuolar secretion pathway in biofilm formation and virulence in Candida albicans, we cloned and analyzed the C. albicans homolog of the Saccharomyces cerevisiae prevacuolar trafficking gene PEP12. C. albicans PEP12 encodes a deduced t-SNARE that is 28% identical to S. cerevisiae Pep12p, and plasmids bearing C. albicans PEP12 complemented the abnormal vacuolar morphology and temperature-sensitive growth of an S. cerevisiae pep12 null mutant. The C. albicans pep12 Delta null mutant was defective in endocytosis and vacuolar acidification and accumulated 40- to 60-nm cytoplasmic vesicles near the plasma membrane. Secretory defects included increased extracellular proteolytic activity and absent lipolytic activity. The pep12Delta null mutant was more sensitive to cell wall stresses and antifungal agents than the isogenic complemented strain or the control strain DAY185. Notably, the biofilm formed by the pep12Delta mutant was reduced in overall mass and fragmented completely upon the slightest disturbance. The pep12Delta mutant was markedly reduced in virulence in an in vitro macrophage infection model and an in vivo mouse model of disseminated candidiasis. These results suggest that C. albicans PEP12 plays a key role in biofilm integrity and in vivo virulence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.