ArticleJournal of bacteriology2010
Manipulating each MreB of Bdellovibrio bacteriovorus gives diverse morphological and predatory phenotypes.
Article in Journal of bacteriology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 43 citations in OpenAlex.
- Effects of orally administered Bdellovibrio bacteriovorus on the well-being and Salmonella colonization of young chicks.Applied and environmental microbiology · 2011Trial
- Predatory potentials of novel3 Biotech · 2025Article
- Controlling the expression of heterologous genes in Bdellovibrio bacteriovorus using synthetic biology strategies.Microbial biotechnology · 2024Article
- Advances in cellular and molecular predatory biology ofFrontiers in microbiology · 2023Review
- The potential of facultative predatoryFrontiers in microbiology · 2022Review
- DivIVA Controls Progeny Morphology and Diverse ParA Proteins Regulate Cell Division or Gliding Motility inFrontiers in microbiology · 2020Article
- Nucleotide signaling pathway convergence in a cAMP-sensing bacterial c-di-GMP phosphodiesterase.The EMBO journal · 2019Article
- Shedding Light on the Cell Biology of the Predatory BacteriumFrontiers in microbiology · 2019Article
- Prokaryotic cytoskeletons: protein filaments organizing small cells.Nature reviews. Microbiology · 2018Review
- Is Longitudinal Division in Rod-Shaped Bacteria a Matter of Swapping Axis?Frontiers in microbiology · 2018Review
- Fluorescent D-amino-acids reveal bi-cellular cell wall modifications important for Bdellovibrio bacteriovorus predation.Nature microbiology · 2017Article
- Attack-Phase Bdellovibrio bacteriovorus Responses to Extracellular Nutrients Are Analogous to Those Seen During Late Intraperiplasmic Growth.Microbial ecology · 2017Article
- Bacterial Cell Division: Nonmodels Poised to Take the Spotlight.Annual review of microbiology · 2017Review
- Diverse, uncultivated bacteria and archaea underlying the cycling of dissolved protein in the ocean.The ISME journal · 2016Article
- Interrupting peptidoglycan deacetylation during Bdellovibrio predator-prey interaction prevents ultimate destruction of prey wall, liberating bacterial-ghosts.Scientific reports · 2016Article
- Structural Insights into Protein-Protein Interactions Involved in Bacterial Cell Wall Biogenesis.Antibiotics (Basel, Switzerland) · 2016Review
- Bacterial predator-prey dynamics in microscale patchy landscapes.Proceedings. Biological sciences · 2016Article
- Visualizing Bdellovibrio bacteriovorus by Using the tdTomato Fluorescent Protein.Applied and environmental microbiology · 2015Article
- Ankyrin-mediated self-protection during cell invasion by the bacterial predator Bdellovibrio bacteriovorus.Nature communications · 2015Article
- Bacterial actin and tubulin homologs in cell growth and division.Current biology : CB · 2015Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
We studied the two mreB genes, encoding actinlike cytoskeletal elements, in the predatory bacterium Bdellovibrio bacteriovorus. This bacterium enters and replicates within other Gram-negative bacteria by attack-phase Bdellovibrio squeezing through prey outer membrane, residing and growing filamentously in the prey periplasm forming an infective "bdelloplast," and septating after 4 h, once the prey contents are consumed. This lifestyle brings challenges to the Bdellovibrio cytoskeleton. Both mreB genes were essential for viable predatory growth, but C-terminal green fluorescent protein tagging each separately with monomeric teal-fluorescent protein (mTFP) gave two strains with phenotypic changes at different stages in predatory growth and development. MreB1-mTFP cells arrested growth early in bdelloplast formation, despite successful degradation of prey nucleoid. A large population of stalled bdelloplasts formed in predatory cultures and predation proceeded very slowly. A small proportion of bdelloplasts lysed after several days, liberating MreB1-mTFP attack-phase cells of wild-type morphology; this process was aided by subinhibitory concentrations of an MreB-specific inhibitor, A22. MreB2-mTFP, in contrast, was predatory at an almost wild-type rate but yielded attack-phase cells with diverse morphologies, including spherical, elongated, and branched, the first time such phenotypes have been described. Wild-type predatory rates were seen for all but spherical morphotypes, and septation of elongated morphotypes was achieved by the addition of A22.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.