ArticleThe Journal of biological chemistry2010
Stimulation of inducible nitric oxide by hepatitis B virus transactivator protein HBx requires MTA1 coregulator.
Article in The Journal of biological chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 45 citations in OpenAlex.
- Impact of circ-0000221 in the Pathogenesis of Hepatocellular via Modulation of miR-661-PTPN11 mRNA Axis.Pharmaceutics · 2022Article
- The Biological Function of Hepatitis B Virus X Protein in Hepatocellular Carcinoma.Oncology research · 2019Article
- Hepatitis B virus X protein-mediated non-coding RNA aberrations in the development of human hepatocellular carcinoma.Experimental & molecular medicine · 2017Review
- Article
- HBX Protein-Induced Downregulation of microRNA-18a is Responsible for Upregulation of Connective Tissue Growth Factor in HBV Infection-Associated Hepatocarcinoma.Medical science monitor : international medical journal of experimental and clinical research · 2016Article
- Molecular alterations in hepatocellular carcinoma associated with hepatitis B and hepatitis C infections.Oncotarget · 2016Review
- miRNAs regulated by estrogens, tamoxifen, and endocrine disruptors and their downstream gene targets.Molecular and cellular endocrinology · 2015Review
- Nitric oxide in liver diseases.Trends in pharmacological sciences · 2015Review
- Post-transcriptional regulation of MTA family by microRNAs in the context of cancer.Cancer metastasis reviews · 2014Review
- Role of hepatitis B virus DNA integration in human hepatocarcinogenesis.World journal of gastroenterology · 2014Review
- Hepatitis B virus X protein-induced aberrant epigenetic modifications contributing to human hepatocellular carcinoma pathogenesis.Molecular and cellular biology · 2013Review
- Epigenetic control of metastasis-associated protein 1 gene expression by hepatitis B virus X protein during hepatocarcinogenesis.Oncogenesis · 2012Article
- miRNAs and estrogen action.Trends in endocrinology and metabolism: TEM · 2012Review
- Metastasis-associated protein 3 (MTA3) regulates G2/M progression in proliferating mouse granulosa cells.Biology of reproduction · 2012Article
- Metastasis-associated protein 1/nucleosome remodeling and histone deacetylase complex in cancer.Cancer research · 2012Review
- Inflammatory response to liver fluke Opisthorchis viverrini in mice depends on host master coregulator MTA1, a marker for parasite-induced cholangiocarcinoma in humans.Hepatology (Baltimore, Md.) · 2011Article
- Hepatitis B virus X gene and hepatocarcinogenesis.Journal of gastroenterology · 2011Review
- The metastasis-associated protein-1 gene encodes a host permissive factor for schistosomiasis, a leading global cause of inflammation and cancer.Hepatology (Baltimore, Md.) · 2011Article
- MTA1 coregulation of transglutaminase 2 expression and function during inflammatory response.The Journal of biological chemistry · 2011Article
- Nitric oxide: perspectives and emerging studies of a well known cytotoxin.International journal of molecular sciences · 2010Review
Corrections and comments
- Retraction · 2017-03-17Error in Image · Investigation by Company/Institution · · Article earlier subject to Expression of Concern;
- Expression of concern · 2016-01-15Concerns/Issues about Data · Concerns/Issues about Results and/or Conclusions · Investigation by Company/Institution · · Article later retracted;
- Expression of concern
- Retracted
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Nitric oxide has been implicated in the pathogenesis of inflammatory disorders, including hepatitis B virus-associated hepatocellular carcinoma. Transactivator protein HBx, a major regulator of cellular responses of hepatitis B virus, is known to induce the expression of MTA1 (metastasis-associated protein 1) coregulator via NF-kappaB signaling in hepatic cells. However, the underlying mechanism of HBx regulation of the inducible nitric-oxide synthase (iNOS) pathway remains unknown. Here we provide evidence that MTA1 is a positive regulator of iNOS transcription and plays a mechanistic role in HBx stimulation of iNOS expression and activity. We found that the HBx-MTA1 complex is recruited onto the human iNOS promoter in an NF-kappaB-dependent manner. Pharmacological inhibition of the NF-kappaB signaling prevented the ability of HBx to stimulate the transcription, the expression, and the activity of iNOS; nevertheless, these effects could be substantially rescued by MTA1 dysregulation. We further discovered that HBx-mediated stimulation of MTA1 is paralleled by the suppression of miR-661, a member of the small noncoding RNAs, recently shown to target MTA1. We observed that miR-661 controls of MTA1 expression contributed to the expression and activity of iNOS in HBx-expressing HepG2 cells. Accordingly, depletion of MTA1 by either miR-661 or siRNA in HBx-expressing cells severely impaired the ability of HBx to modulate the endogenous levels of iNOS and nitrite production. Together, these findings reveal an inherent role of MTA1 in HBx regulation of iNOS expression and consequently its function in the liver cancer cells.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.