ArticleAmerican journal of obstetrics and gynecology2010
Dose-response effects of betamethasone on maturation of the fetal sheep lung.
Article in American journal of obstetrics and gynecology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 33 citations in OpenAlex.
- Respiratory evolution after antenatal betamethasone dose reduction in very preterm neonates: a post hoc analysis of the BETADOSE trial.European journal of pediatrics · 2026Trial
- Blood Glucose Response after Betamethasone Injection in Pregnant Women without Diabetes.Annals of African medicine · 2026Observational
- Dexamethasone dosage and course effects on respiratory outcomes in preterm twins: retrospective cohort study.Scientific reports · 2025Article
- What is the evidence? Updates in the use of antenatal corticosteroids for patients at risk of preterm birth.European journal of obstetrics & gynecology and reproductive biology: X · 2024Review
- A case-control study on the effects of incomplete, one, and more than one dexamethasone course on acute respiratory problems in preterm neonates born between 28BMC pregnancy and childbirth · 2022Article
- Association between betamethasone levels and respiratory distress syndrome in preterm births: A prospective cohort study.Clinical and translational science · 2022Article
- Full versus half dose of antenatal betamethasone to prevent severe neonatal respiratory distress syndrome associated with preterm birth: study protocol for a randomised, multicenter, double blind, placebo-controlled, non-inferiority trial (BETADOSE).BMC pregnancy and childbirth · 2019Article
- Feasibility of 2-D ultrasound shear wave elastography of fetal lungs in case of threatened preterm labour: a study protocol.BMJ open · 2017Article
- Influence of antenatal glucocorticoid on preterm lamb diaphragm.Pediatric research · 2017Article
- Dose-dependent effects of glucocorticoids on pulmonary vascular development in a murine model of hyperoxic lung injury.Pediatric research · 2016Article
- Measurement of betamethasone concentration in maternal serum treated for fetal lung maturity; Is it feasible?Reproductive biology and endocrinology : RB&E · 2016Article
- Antioxidant treatment improves neonatal survival and prevents impaired cardiac function at adulthood following neonatal glucocorticoid therapy.The Journal of physiology · 2013Article
- Elevated glucocorticoids during ovine pregnancy increase appetite and produce glucose dysregulation and adiposity in their granddaughters in response to ad libitum feeding at 1 year of age.American journal of obstetrics and gynecology · 2013Article
- LPS-induced chorioamnionitis and antenatal corticosteroids modulate Shh signaling in the ovine fetal lung.American journal of physiology. Lung cellular and molecular physiology · 2012Article
- Growth and insulin dynamics in two generations of female offspring of mothers receiving a single course of synthetic glucocorticoids.American journal of obstetrics and gynecology · 2012Article
- Controversy: antenatal steroids.Clinics in perinatology · 2011Review
- Chronic lung disease in preterm lambs: effect of daily vitamin A treatment on alveolarization.American journal of physiology. Lung cellular and molecular physiology · 2010Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
Abstract
objectiveGlucocorticoid administration to women in preterm labor improves neonatal mortality and morbidity. Fetal exposure to glucocorticoid levels higher than those appropriate to the current gestational stage has multiple organ system effects. Some, eg, fetal hypertension, are maximal at lower than the clinical dose. We hypothesized that the clinical dose has supramaximal lung maturational effects. STUDY
designWe evaluated the full, half, and quarter clinical betamethasone dose (12 mg/70 kg or 170 microg/kg intramuscularly twice 24 hours apart) on fetal sheep lung pressure volume curves (PVC) after 48 hours' exposure at 0.75 gestation. We measured key messenger RNAs and protein products that affect lung function and total lung dipalmitoyl phosphatidyl choline.
resultsFull and half doses had similar PVC and total lung dipalmitoyl phosphatidyl choline effects. Messenger RNA for surfactant proteins A, B, and D and elastin increased in a dose-dependent fashion.
conclusionHalf the clinical betamethasone dose produces maximal PVC improvement in fetal sheep at 0.75 gestation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.