ArticleJournal of clinical virology : the official publication of the Pan American Society for Clinical Virology2010
Correlation between bocavirus infection and humoral response, and co-infection with other respiratory viruses in children with acute respiratory infection.
Article in Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed.
- Human bocavirus in the nasopharynx of otitis-prone children.International journal of pediatric otorhinolaryngology · 2012Trial
- Twenty years of human bocavirus research: from an unculturable virus of unclear pathogenicity to a culturable human pathogen and gene therapy vector candidate.Clinical microbiology reviews · 2025Review
- Human bocavirus NP1 antagonizes host type I interferon response through repressing the nuclear transport of STAT1.Virulence · 2025Article
- Human Bocavirus Circulating in Patients with Acute Gastroenteritis in Taiwan, 2018-2022.Viruses · 2024Article
- Article
- Exploring the Impact of Antibiotics on Fever Recovery Time and Hospital Stays in Children with Viral Infections: Insights from Advanced Data Analysis.Antibiotics (Basel, Switzerland) · 2024Article
- Development of RPA-Cas12a-fluorescence assay for rapid and reliable detection of human bocavirus 1.Animal models and experimental medicine · 2024Article
- Viral Coinfection of Children Hospitalized with Severe Acute Respiratory Infections during COVID-19 Pandemic.Biomedicines · 2023Article
- Human Bocavirus in Childhood: A True Respiratory Pathogen or a "Passenger" Virus? A Comprehensive Review.Microorganisms · 2023Review
- The prevalence of human bocavirus in <2-year-old children with acute bronchiolitis.New microbes and new infections · 2020Review
- Human Bocavirus 1 Infection of Well-Differentiated Human Airway Epithelium.Current protocols in microbiology · 2020Article
- Human bocavirus infections and co-infections with respiratory syncytial virus and Rotavirus in children with acute respiratory or gastrointestinal disease.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2020Article
- The 5' Untranslated Region of Human Bocavirus Capsid Transcripts Regulates Viral mRNA Biogenesis and Alternative Translation.Journal of virology · 2018Article
- Epidemiology of HBoV1 infection and relationship with meteorological conditions in hospitalized pediatric patients with acute respiratory illness: a 7-year study in a subtropical region.BMC infectious diseases · 2018Article
- Respiratory Virus Infections in Hematopoietic Cell Transplant Recipients.Frontiers in microbiology · 2018Review
- Human bocavirus 1 infection of CACO-2 cell line cultures.Virology · 2017Article
- Relative Abundance of Human Bocaviruses in Urban Sewage in Greater Cairo, Egypt.Food and environmental virology · 2017Article
- Parvovirus Expresses a Small Noncoding RNA That Plays an Essential Role in Virus Replication.Journal of virology · 2017Article
- Human Parvoviruses.Clinical microbiology reviews · 2017Review
- Is the role of rhinoviruses as causative agents of pediatric community-acquired pneumonia over-estimated?European journal of pediatrics · 2016Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHuman bocavirus (HBoV), a recently discovered virus, is prevalent among children with respiratory tract infection throughout the world. Co-infection was frequently found in HBoV-positive patients. Thus, whether HBoV is responsible for the respiratory disease is still arguable.
objectivesA comprehensive study was carried out to integrate clinical and virological prevalence in HBoV-positive outpatient children, and to determine genetic and serologic characteristics of HBoV in Shanghai, China. STUDY
designNasal/throat swabs and sera were obtained over a 2-year period from 817 children with respiratory tract infection to examine the presence of HBoV and its co-infection. The seroepidemiology of HBoV was studied by ELISA and Western blot against the capsid protein VP2-based fragment. Persistence of HBoV was also analyzed in 12 pairs of return-visit cases.
resultsHBoV was identified in 96 samples (11.8%). The co-infection rate with other respiratory viruses was 51%. IgM was detected in 55.7% of HBoV RT-PCR-positive patients, and in 72.7% of those who had high viral genome load. In addition, persistent viral DNA positivity was detected in 10 of 12 HBoV-positive cases tested, an average of 14 days later, and one child was still HBoV-positive after 31 days.
conclusionHBoV was found frequently in children with respiratory tract symptoms associated with other respiratory viruses, and persisted in the respiratory tract and in serum and urine. The presence of IgM was significantly more prevalent in viremic patients and those diagnosed with high load of HBoV DNA in nasal/throat swabs.
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