Trial reportThe Journal of clinical psychiatry2010
Obesity and onset of significant depressive symptoms: results from a prospective community-based cohort study of older men and women.
Trial report in The Journal of clinical psychiatry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
68 citing papers in PubMed, 3 syntheses or guidelines pooled it, 149 citations in OpenAlex.
- Depression and obesity among females, are sex specificities considered?Archives of women's mental health · 2021Pooled it
- Fat compartments in patients with depression: A meta-analysis.Brain and behavior · 2021Pooled it
- Hypertension and risk of depression in the elderly: a meta-analysis of prospective cohort studies.Journal of human hypertension · 2015Pooled it
- PPAR-γ agonism as a modulator of mood: proof-of-concept for pioglitazone in bipolar depression.CNS drugs · 2014Trial
- Effect of weight reduction on the quality of life in obese patients with fibromyalgia syndrome: a randomized controlled trial.Clinical rheumatology · 2012Trial
- Ziprasidone with adjunctive mood stabilizer in the maintenance treatment of bipolar I disorder: long-term changes in weight and metabolic profiles.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2012Trial
- Use of insulin sensitizers for the treatment of major depressive disorder: a pilot study of pioglitazone for major depression accompanied by abdominal obesity.Journal of affective disorders · 2012Trial
- J-shaped association between body roundness index and depression: A large-scale cross-sectional study.Medicine · 2026Article
- High prevalence of depression in symptomatic knee osteoarthritis: a cross-sectional study on risk factors and therapeutic implications.BMC musculoskeletal disorders · 2025Observational
- The relationship between VAI, LAP, and depression and the mediation role of sleep duration-evidence from NHANES 2005-2020.BMC psychiatry · 2025Article
- Metabolic/bariatric clinical practice in Lagos, Nigeria: a retrospective review of the cases and outcomes of our 10-year experience.The Pan African medical journal · 2025Article
- The influencing of obesity on lung ventilation function among middle-aged and elderly people.Scientific reports · 2024Article
- Influence of Metabolic Dysregulation in the Management of Depressive Disorder-Narrative Review.Nutrients · 2024Review
- Association between visceral adiposity and generalized anxiety disorder (GAD).BMC psychology · 2024Article
- Article
- Considerations for Optimizing Warfighter Psychological Health with a Research-Based Flavonoid Approach: A Review.Nutrients · 2023Review
- Excess body weight and specific types of depressive symptoms: Is there a mediating role of systemic low-grade inflammation?Brain, behavior, and immunity · 2023Article
- Plasma complement C3 and C3a are increased in major depressive disorder independent of childhood trauma.BMC psychiatry · 2022Article
- Network structure of time-varying depressive symptoms through dynamic time warp analysis in late-life depression.International journal of geriatric psychiatry · 2022Article
- Burden of disease study of overweight and obesity; the societal impact in terms of cost-of-illness and health-related quality of life.BMC public health · 2022Article
8 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
objectiveAlthough several cross-sectional studies have linked obesity and depression, less is known about their longitudinal association and about the relative influence of obesity subtypes. We prospectively examined whether obesity (specifically, abdominal) increased the risk of onset of depression in a population-based sample of older persons.
methodParticipants were 2,547 nondepressed, well-functioning white and black persons, aged 70-79 years, enrolled in the Health, Aging, and Body Composition Study, an ongoing prospective community-based cohort study. Baseline measurements were conducted between April 1997 and June 1998. Overall obesity was assessed by body mass index (BMI) and percent body fat (measured by dual energy x-ray absorptiometry), whereas abdominal obesity measures included waist circumference, sagittal diameter, and visceral fat (measured by computer tomography). Onset of significant depressive symptoms was defined as a Center for Epidemiologic Studies Depression 10-item score > or = 10 at any annual follow-up over 5 years and/or new antidepressant medication use. Persistent depression was defined as depression at 2 consecutive follow-up visits.
resultsOver 5 years, significant depressive symptoms emerged in 23.7% of initially nondepressed persons. In men, both overall (BMI: hazard ratio [HR] per SD increase = 1.20; 95% CI, 1.03-1.40) and abdominal obesity (visceral fat: HR per SD increase = 1.19; 95% CI, 1.07-1.33) predicted onset of depressive symptoms after adjustment for sociodemographics. When BMI and visceral fat were adjusted for each other, only visceral fat was significantly associated with depression onset (HR = 1.18; 95% CI, 1.04-1.34). Stronger associations were found for persistent depressive symptoms. No associations were found in women.
conclusionThis study shows that obesity, in particular visceral fat, increases the risk of onset of significant depressive symptoms in men. These results suggest that specific mechanisms might relate visceral fat to the onset of depression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.