ArticleBMC microbiology2009
Multilocus sequence typing supports the hypothesis that Ochrobactrum anthropi displays a human-associated subpopulation.
Article in BMC microbiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22 citing papers in PubMed.
- Evaluation of a Multilocus Variable-Number Tandem-Repeat Analysis Scheme for TypingMicroorganisms · 2024Article
- Development of an efficient marker-free soybean transformation method using the novel bacterium Ochrobactrum haywardense H1.Plant biotechnology journal · 2022Article
- Onchycobacter anthropi Pyomyositis in Immunocompetent Patient: Case Report.Journal of orthopaedic case reports · 2022Article
- Comprehensive screening of genomic and metagenomic data reveals a large diversity of tetracycline resistance genes.Microbial genomics · 2020Article
- Application of Whole Genome Sequencing and Pan-Family Multi-Locus Sequence Analysis to Characterize Relationships Within the FamilyFrontiers in microbiology · 2020Article
- Gene Transfer Agents in Symbiotic Microbes.Results and problems in cell differentiation · 2020Review
- Ochrobactrum cytisi IPA7.2 promotes growth of potato microplants and is resistant to abiotic stress.World journal of microbiology & biotechnology · 2019Article
- Taxonomic Organization of the FamilyFrontiers in microbiology · 2019Article
- Morphological responses to nitrogen stress deficiency of a new heterotrophic isolated strain of Ebro Delta microbial mats.Protoplasma · 2019Article
- Are animals a source of Stenotrophomonas maltophilia in human infections? Contributions of a nationwide molecular study.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2018Article
- Correct Identification ofFrontiers in medicine · 2018Article
- The native microbiome of the nematode Caenorhabditis elegans: gateway to a new host-microbiome model.BMC biology · 2016Article
- Draft Genome Sequence of Ochrobactrum anthropi Strain ML7 Isolated from Soil Samples in Vinhphuc Province, Vietnam.Genome announcements · 2015Article
- Article
- Niches, population structure and genome reduction in Ochrobactrum intermedium: clues to technology-driven emergence of pathogens.PloS one · 2014Article
- Clinical characteristics of Ochrobactrum anthropi bacteremia.Journal of clinical microbiology · 2013Article
- Phylogenetic analysis and polyphasic characterization of Clavibacter michiganensis strains isolated from tomato seeds reveal that nonpathogenic strains are distinct from C. michiganensis subsp. michiganensis.Applied and environmental microbiology · 2012Article
- The shared antibiotic resistome of soil bacteria and human pathogens.Science (New York, N.Y.) · 2012Article
- Multilocus genetics to reconstruct aeromonad evolution.BMC microbiology · 2012Article
- From environment to man: genome evolution and adaptation of human opportunistic bacterial pathogens.Genes · 2012Article
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8 authors.
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Abstract
backgroundOchrobactrum anthropi is a versatile bacterial species with strains living in very diverse habitats. It is increasingly recognized as opportunistic pathogen in hospitalized patients. The population biology of the species particularly with regard to the characteristics of the human isolates is being investigated. To address this issue, we proposed a polyphasic approach consisting in Multi-Locus Sequence Typing (MLST), multi-locus phylogeny, genomic-based fingerprinting by pulsed-field gel electrophoresis (PFGE) and antibiotyping.
resultsWe tested a population of 70 O. anthropi clinical (n = 43) and environmental (n = 24) isolates as well as the type strain O. anthropi ATCC49188T and 2 strains of Ochrobactrum lupini and Ochrobactrum cytisi isolated from plant nodules. A Multi-Locus Sequence Typing (MLST) scheme for O. anthropi is proposed here for the first time. It was based on 7 genes (3490 nucleotides) evolving mostly by neutral mutations. The MLST approach suggested an epidemic population structure. A major clonal complex corresponded to a human-associated lineage since it exclusively contained clinical isolates. Genomic fingerprinting separated isolates displaying the same sequence type but it did not detect a population structure that could be related to the origin of the strains. None of the molecular method allowed the definition of particular lineages associated to the host-bacteria relationship (carriage, colonisation or infection). Antibiotyping was the least discriminative method.
conclusionThe results reveal a human-associated subpopulation in our collection of strains. The emergence of this clonal complex was probably not driven by the antibiotic selective pressure. Therefore, we hypothesise that the versatile species O. anthropi could be considered as a human-specialized opportunistic pathogen.
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