ArticleBMC microbiology2009
YsxC, an essential protein in Staphylococcus aureus crucial for ribosome assembly/stability.
Article in BMC microbiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 34 citations in OpenAlex.
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- Coordination of Chromosome Segregation and Cell Division inFrontiers in microbiology · 2017Article
- Streptococcus pyogenes polymyxin B-resistant mutants display enhanced ExPortal integrity.Journal of bacteriology · 2014Article
- Clonal expansion during Staphylococcus aureus infection dynamics reveals the effect of antibiotic intervention.PLoS pathogens · 2014Article
- A privileged intraphagocyte niche is responsible for disseminated infection of Staphylococcus aureus in a zebrafish model.Cellular microbiology · 2012Article
- Potassium acts as a GTPase-activating element on each nucleotide-binding domain of the essential Bacillus subtilis EngA.PloS one · 2012Article
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- 3D-SIM super resolution microscopy reveals a bead-like arrangement for FtsZ and the division machinery: implications for triggering cytokinesis.PLoS biology · 2012Article
- Molecular dynamics simulation of the Staphylococcus aureus YsxC protein: molecular insights into ribosome assembly and allosteric inhibition of the protein.Journal of molecular modeling · 2011Article
- The universally conserved prokaryotic GTPases.Microbiology and molecular biology reviews : MMBR · 2011Review
- Structure of an essential GTPase, YsxC, from Thermotoga maritima.Acta crystallographica. Section F, Structural biology and crystallization communications · 2011Article
- From complete genome sequence to 'complete' understanding?Trends in biotechnology · 2010Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
backgroundBacterial growth and division requires a core set of essential proteins, several of which are still of unknown function. They are also attractive targets for the development of new antibiotics. YsxC is a member of a family of GTPases highly conserved across eubacteria with a possible ribosome associated function.
resultsHere, we demonstrate by the creation of a conditional lethal mutant that ysxC is apparently essential for growth in S. aureus. To begin to elucidate YsxC function, a translational fusion of YsxC to the CBP-ProteinA tag in the staphylococcal chromosome was made, enabling Tandem Affinity Purification (TAP) of YsxC-interacting partners. These included the ribosomal proteins S2, S10 and L17, as well as the beta' subunit of the RNA polymerase. YsxC was then shown to copurify with ribosomes as an accessory protein specifically localizing to the 50 S subunit. YsxC depletion led to a decrease in the presence of mature ribosomes, indicating a role in ribosome assembly and/or stability in S. aureus.
conclusionsIn this study we demonstrate that YsxC of S. aureus localizes to the ribosomes, is crucial for ribosomal stability and is apparently essential for the life of S. aureus.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.