ReviewCurrent molecular pharmacology2009
Induced pluripotent stem cells, new tools for drug discovery and new hope for stem cell therapies.
Review in Current molecular pharmacology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed.
- Induced pluripotent stem cells (iPSCs): molecular mechanisms of induction and applications.Signal transduction and targeted therapy · 2024Review
- Generating Homogeneous Brain Organoids from Human iPSCs.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Induced neural stem/precursor cells for fundamental studies and potential application in neurodegenerative diseases.Neuroscience bulletin · 2015Review
- Scalable 96-well Plate Based iPSC Culture and Production Using a Robotic Liquid Handling System.Journal of visualized experiments : JoVE · 2015Article
- Electrically guiding migration of human induced pluripotent stem cells.Stem cell reviews and reports · 2011Article
- In vitro mesenchymal stem cell differentiation after mechanical stimulation.Cell proliferation · 2011Article
- Histone deacetylases in neural stem cells and induced pluripotent stem cells.Journal of biomedicine & biotechnology · 2011Review
- Spinal muscular atrophy: mechanisms and therapeutic strategies.Human molecular genetics · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
Somatic cell nuclear transfer or therapeutic cloning has provided great hope for stem cell-based therapies. However, therapeutic cloning has been experiencing both ethical and technical difficulties. Recent breakthrough studies using a combination of four factors to reprogram human somatic cells into pluripotent stem cells without using embryos or eggs have led to an important revolution in stem cell research. Comparative analysis of human induced pluripotent stem cells and human embryonic stem cells using assays for morphology, cell surface marker expression, gene expression profiling, epigenetic status, and differentiation potential have revealed a remarkable degree of similarity between these two pluripotent stem cell types. This mini-review summarizes these ground-breaking studies. These advances in reprogramming will enable the creation of patient-specific stem cell lines to study various disease mechanisms. The cellular models created will provide valuable tools for drug discovery. Furthermore, this reprogramming system provides great potential to design customized patient-specific stem cell therapies with economic feasibility.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.