ArticleToxicology mechanisms and methods2008
Metabolomics in lung inflammation:a high-resolution (1)h NMR study of mice exposedto silica dust.
Article in Toxicology mechanisms and methods, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 75 citations in OpenAlex.
- Results from omic approaches in rat or mouse models exposed to inhaled crystalline silica: a systematic review.Particle and fibre toxicology · 2024Pooled it
- Impaired AMPK control of alveolar epithelial cell metabolism promotes pulmonary fibrosis.JCI insight · 2025Article
- Identification and pathway analysis of metabolic biomarkers of gastric acid aspiration-induced lung injury in mice.European journal of medical research · 2025Article
- Stability and structure-activity relationship of the SPA4 peptide under ambient and stressed conditions of lung injury.RSC advances · 2023Article
- Metabolomics profile in acute respiratory distress syndrome by nuclear magnetic resonance spectroscopy in patients with community-acquired pneumonia.Respiratory research · 2022Article
- Metabolic requirements of pulmonary fibrosis: role of fibroblast metabolism.The FEBS journal · 2021Review
- Metabolomic profiling of extraesophageal reflux disease in children.Clinical and translational science · 2021Observational
- NMR-Based Metabolomics in Cancer Research.Advances in experimental medicine and biology · 2021Article
- Metabolomic and metallomic profile differences between Veterans and Civilians with Pulmonary Sarcoidosis.Scientific reports · 2019Article
- The Klebsiella pneumoniae citrate synthase gene, gltA, influences site specific fitness during infection.PLoS pathogens · 2019Article
- Zinc oxide nanoparticles impose metabolic toxicity by de-regulating proteome and metabolome inToxicology reports · 2019Article
- Bio-Inspired Silver Nanoparticles Impose Metabolic and Epigenetic Toxicity toFrontiers in pharmacology · 2019Article
- Nuclear magnetic resonance-based metabolomic investigation reveals metabolic perturbations in PMEnvironmental science and pollution research international · 2018Article
- Overview of carbon and nitrogen catabolite metabolism in the virulence of human pathogenic fungi.Molecular microbiology · 2018Review
- Metabolomic Analysis of Mice Exposed to Gamma Radiation Reveals a Systemic Understanding of Total-Body Exposure.Radiation research · 2017Article
- Metabolomics based predictive biomarker model of ARDS: A systemic measure of clinical hypoxemia.PloS one · 2017Article
- Magic Angle Spinning NMR Metabolomics.Metabolomics : open access · 2016Article
- A high-resolution 2D J-resolved NMR detection technique for metabolite analyses of biological samples.Scientific reports · 2015Article
- Article
- Metabolomics of bronchoalveolar lavage differentiate healthy HIV-1-infected subjects from controls.AIDS research and human retroviruses · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
ABSTRACT Here we report the first (1)H NMR metabolomics studies on excised lungs and bronchoalveolar lavage fluid (BALF) from mice exposed to crystalline silica. High-resolution (1)H NMR metabolic profiling on intact excised lungs was performed using slow magic angle sample spinning (slow-MAS) (1)H PASS (phase-altered spinning sidebands) at a sample spinning rate of 80 Hz. Metabolic profiling on BALF was completed using fast magic angle spinning at 2 kHz. Major findings are that the relative concentrations of choline, phosphocholine (PC), and glycerophosphocholine (GPC) were statistically significantly increased in silica-exposed mice compared to sham controls, indicating an altered membrane choline phospholipids metabolism (MCPM). The relative concentrations of glycogen/glucose, lactate, and creatine were also statistically significantly increased in mice exposed to silica dust, suggesting that cellular energy pathways were affected by silica dust. Elevated levels of glycine, lysine, glutamate, proline, and 4-hydroxyproline were also increased in exposed mice, suggesting the activation of a collagen pathway. Furthermore, metabolic profiles in mice exposed to silica dust were found to be spatially heterogeneous, consistent with regional inflammation revealed by in vivo magnetic resonance imaging (MRI).
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.