Evidence map›Paper›PMID 20020333›Full record

Trial reportClinical orthopaedics and related research2010

The efficacy of periarticular multimodal drug infiltration in total hip arthroplasty.

Constant A Busch, Michael R Whitehouse, Benjamin J Shore, Steven J MacDonald, Richard W McCalden, Robert B Bourne

3 registry-linked trialsOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Clinical orthopaedics and related research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 56 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed, 8 pooled it
7.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02793947 phase4completednot on this mapstarted 2015, after this paper: background citation

Efficacy of Peri-Incisional Multimodal Drug Injection Following Operative Management of Femur Fractures: A Randomized Controlled Trial

TypeinterventionalSponsorUniversity of IowaRan2015 to 2016Enrolled102ConditionsPain, Postoperative, Femur FractureArmsRopivacaine, Epinephrine, Morphine, 0.9% sodium chloride solution
NCT05325671 nacompletednot on this mapstarted 2022, after this paper: background citation

Efficacy of Postoperative Pain Control Between Transarticular VS Periartiucular Multimodal Drug Infiltration in Total Hip Arthroplasty: Double-blinded Randomized Control Trial

TypeinterventionalSponsorDepartment of Medical Services Ministry of Public Health of ThailandRan2022 to 2023Enrolled120ConditionsPain, Post Operative, Arthroplasty ComplicationsArmstransarticular multimodal drug infiltration
NCT05898581 narecruitingnot on this mapstarted 2024, after this paper: background citation

Ultrasound-guided Pericapsular Nerve Group (PENG) Block vs. Intraoperative Local Anesthetic Infiltration (ILAI) for Total Hip Arthroplasty (THA): a Single Center, Non-inferiority Randomized Control Trial Pilot Study.

TypeinterventionalSponsorLondon Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph'sRan2024 to 2026Enrolled60ConditionsAnesthesiaArmsPENG Block, Control Group
3 · Its place in the literature

Who cites it

56 citing papers in PubMed, 8 syntheses or guidelines pooled it, 156 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 3 countries.

Constant A BuschAshford and St Peter's Hospital NHS Trust, Chertsey, Surrey, England.
Michael R Whitehouse
Benjamin J Shore
Steven J MacDonald
Richard W McCalden
Robert B Bourne
London Health Sciences Centre · CAAshford and St Peter's Hospitals NHS Foundation Trust · GBS.P.E.C.I.E.S. · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPatient-controlled analgesia is a widely used and effective method of controlling pain after THA. This method is associated with substantial undesirable side effects. Local infiltration has been introduced in an attempt to reduce opioid requirements postoperatively, but its ability to reduce pain without complications is still questioned. QUESTIONS/PURPOSES: We evaluated patient-controlled analgesia use, pain and satisfaction scores, complication rates, and ropivacaine levels associated with the use of periarticular multimodal drug infiltration in THA. PATIENTS AND

methodsWe randomized 64 patients undergoing THA to receive a periarticular intraoperative multimodal drug injection or to receive no injection. All patients received patient-controlled analgesia for 24 hours after surgery. The final assessment was at 6 weeks.

resultsPatients receiving the periarticular injection used less patient-controlled analgesia 6 hours postoperatively. The 24-hour patient-controlled analgesia requirement postsurgery also was less. The visual analog scale score for pain on activity in the postanesthetic care unit was less for patients who received an injection. The visual analog scale satisfaction score was similar in the two groups throughout the followup period. Recorded unbound ropivacaine levels were 2.5 times lower than toxic levels.

conclusionsPeriarticular intraoperative injection with multimodal drugs can reduce postoperative patient-controlled analgesia requirements and pain on activity in patients undergoing THA with no apparent increase in risk. LEVEL OF EVIDENCE: Level I, therapeutic study. See the guidelines online for a complete description of level of evidence.

Indexed as

Arthroplasty, Replacement, HipAdultAgedAged, 80 and overAmidesAnalgesia, Patient-ControlledAnalgesicsAnalgesics, OpioidAnesthetics, LocalAnti-Inflammatory Agents, Non-SteroidalDrug CombinationsEpinephrineFemaleHealth StatusHumansInjections, Intra-ArticularAmidesAnalgesicsAnalgesics, OpioidAnesthetics, LocalAnti-Inflammatory Agents, Non-SteroidalDrug CombinationsEpinephrineKetorolacMorphineRopivacaine

Identifiers

PMID20020333
PMCPMC2895844
OpenAlexW2052145417

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.